CCG258208 hydrochloride GRK2-IN-1 hydrochloride,98.76%
产品编号:Bellancom-109562A| 分子式:C24H26ClFN4O4| 分子量:488.94
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CCG258208 hydrochloride GRK2-IN-1 hydrochloride
产品介绍 | CCG258208 (GRK2-IN-1) hydrochloride 是一种强效和选择性的 GRK2 (G蛋白偶联受体激酶2) 抑制剂 (IC50=30 nM),对 GRK5 (IC50=7.09 μM) 显示出 230 倍的选择性,对 GRK1 (IC50=87.3 μM)、PKA 和 ROCK1 有超过 2500 倍的选择性。CCG258208 hydrochloride 可用于心衰的研究。 | ||||||||||||||||
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生物活性 | CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research. | ||||||||||||||||
体外研究 |
CCG258208 (Compound 14as) (0-1 μM; 10 min) shows significant improvement in βAR-stimulated contractility in mouse cardiomyocytes. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay
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体内研究 (In Vivo) |
CCG258208 (Compound 14as) (intraperitoneal injection; 10 mg/kg; once) treatment shows superior half-life in vivo. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
CCG258208 (Compound 14as) (intraperitoneal injection; 10 mg/kg; once) treatment shows superior half-life in vivo. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
| ||||||||||||||||
体内研究 |
CCG258208 (Compound 14as) (intraperitoneal injection; 10 mg/kg; once) treatment shows superior half-life in vivo. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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性状 | Solid | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (511.31 mM; Need ultrasonic) H2O : 50 mg/mL (102.26 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在 西域 网站选购。
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
参考文献 |
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