DDO-2093 dihydrochloride|西域试剂

DDO-2093 dihydrochloride,98.52%

产品编号：Bellancom-132233A| 分子式：C₂₉H₃₉Cl₃FN₉O₃| 分子量：687.04

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-132233A		￥5800.00	杭州北京（现货）
Bellancom-132233A		￥10500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

DDO-2093 dihydrochloride

产品介绍

DDO-2093 dihydrochloride 是一种有效的 MLL1 和 WDR5 蛋白-蛋白相互作用抑制剂 (IC₅₀=8.6 nM; K_d=11.6 nM)，具有抗肿瘤活性。DDO-2093 dihydrochloride 选择性抑制 MLL 复合物的催化活性。

生物活性

DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC₅₀=8.6 nM; K_d=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.

体外研究

DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression (HOXA9 and Meis1).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	MV4-11 cells
Concentration:	1, 2.5, 5, and 10 μM
Incubation Time:	7 days
Result:	Dose-dependently reduced the mono-, di-, and trimethylation of H3K4.

体内研究
(In Vivo)

DDO-2093 (20-80 mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (MV4-11 human leukemia cancer xenografts)
Dosage:	20, 40, and 80 mg/kg
Administration:	Intraperitoneal injection; every other day for 21 days
Result:	Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.

体内研究

DDO-2093 (20-80 mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (MV4-11 human leukemia cancer xenografts)
Dosage:	20, 40, and 80 mg/kg
Administration:	Intraperitoneal injection; every other day for 21 days
Result:	Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.

体内研究

DDO-2093 (20-80 mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (MV4-11 human leukemia cancer xenografts)
Dosage:	20, 40, and 80 mg/kg
Administration:	Intraperitoneal injection; every other day for 21 days
Result:	Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.