MRS2179 tetrasodium hydrate|西域试剂

MRS2179 tetrasodium hydrate,99.0%

产品编号：Bellancom-101308A| 分子式：C₁₁H₁₃N₅O₉P₂Na₄.3?H₂O| 分子量：576.21

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-101308A		￥5500.00	杭州北京（现货）

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MRS2179 tetrasodium hydrate

产品介绍

MRS2179 tetrasodium hydrate 是一种竞争性 P2Y1 受体拮抗剂，对火鸡 P2Y1 受体的 K_b 值为 102 nM，pA₂ 为 6.99。MRS2179 tetrasodium hydrate 对 P2Y1 的选择性高于 P2X1 (IC₅₀=1.15 µM)、P2X3 (12.9 µM)、P2X2、P2X4、P2Y2、P2Y4 和 P2Y6 受体。MRS2179 tetrasodium hydrate 抑制血小板聚集。

生物活性

MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium hydrate inhibits platelet aggregation.

体外研究

体内研究

MRS2179 tetrasodium hydrate (50 mg/kg; i.p.) prolongs the bleeding time.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CL57BLr6 mice
Dosage:	50 mg/kg
Administration:	Injection into the jugular vein of mice
Result:	The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.

体内研究

MRS2179 tetrasodium hydrate (50 mg/kg; i.p.) prolongs the bleeding time.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CL57BLr6 mice
Dosage:	50 mg/kg
Administration:	Injection into the jugular vein of mice
Result:	The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.