PRMT5-IN-1 hydrochloride
| 产品介绍 | PRMT5 IN-1 hydrochloride (compound 9) 是一种半缩醛胺，是一种有效的选择性蛋白精氨酸甲基转移酶5 (PRMT5) 抑制剂，抑制 PRMT5/MEP50 的 IC50 值为 11 nM。PRMT5 IN-1 hydrochloride 在生理条件下可以转化为醛并与 C449 反应形成共价加合物。 |
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| 生物活性 | PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions. |
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| 性状 | Solid |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| 参考文献 |
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