Fradafiban (BIBU-52) hydrochloride is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a K_d value of 148 nM.

Fradafiban hydrochloride 是精氨酸-甘氨酸-天冬氨酸识别序列的非肽模拟物。 Fradafiban hydrochloride 以高亲和力和选择性结合人血小板 GP IIb/IIIa 复合物，并在体外有效抑制人血小板聚集。 Fradafiban hydrochloride 可逆地结合人血小板 GP IIb/IIIa 复合物，K_d 值为 148 nM。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Fradafiban hydrochloride 仅具有非常有限的口服活性，这可能是由于其高极性，因此口服后吸收较差。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Fradafiban hydrochloride 仅具有非常有限的口服活性，这可能是由于其高极性，因此口服后吸收较差。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8.  [Content Brief]