PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA|西域试剂

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA,99.69%

产品编号：Bellancom-107380A| 分子式：C₁₉H₂₅F₃N₆O₆| 分子量：490.43

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货号	价格	库存与货期
Bellancom-107380A	￥2200.00	杭州北京（现货）
Bellancom-107380A	￥3600.00	杭州北京（现货）
Bellancom-107380A	￥7200.00	杭州北京（现货）

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PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA

产品介绍

PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA) 是一种修饰的促甲状腺激素释放激素 (TRH) 肽，能增强与垂体促甲状腺素释放激素受体的结合，增加垂体促甲状腺素 (TSH) 释放的刺激。PGlu-3-methyl-His-Pro-NH2 TFA 在增强剂乙醇和桉叶碱下，通过大鼠皮肤的体外通透性增加。

生物活性

PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole.

体外研究

PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA) has a very high affinity for the TRH receptor in the CNS. PGlu-3-methyl-His-Pro-NH2 TFA is more potent in eliciting behavioral effects as well as being more potent in the release of both growth hormone and thyroid stimulating hormone.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA) (300 μg/kg; i.v.) elicits a 80 % increase in cerebral blood flow. Even a minute dose of PGlu-3-methyl-His-Pro-NH2 TFA (625 ng kg-1) causes an increase in cerebral blood flow.
The addition of 3% terpene in combination with 47% ethanol increases the penetration of PGlu-3-methyl-His-Pro-NH2 TFA (5 mg/ml; transdermal administration; 30 minutes).
Topical application of PGlu-3-methyl-His-Pro-NH2 TFA induces an increase in TSH serum concentration from 0.32 ng/ml to 22.9 ng/ml, respectively, after 30 min. The addition of Terpene and Ethanol in combination with TRH or PGlu-3-methyl-His-Pro-NH2 TFA, increases the TSH release to 43 and 48.4 ng/ml, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (weighing 296–356 g)
Dosage:	5 mg/ml
Administration:	Transdermal administration; 30 minutes
Result:	Increased in TSH-response in the presence of enhancers (3% Cineole and 47% Ethanol) as compared to peptide without enhancers.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (weighing 296–356 g)
Dosage:	5 mg/ml
Administration:	Transdermal administration; 30 minutes
Result:	Increased in TSH-response in the presence of enhancers (3% Cineole and 47% Ethanol) as compared to peptide without enhancers.

性状

Solid

溶解性数据

In Vitro:

H₂O : 250 mg/mL (509.76 mM; Need ultrasonic)

DMSO : 100 mg/mL (203.90 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0390 mL	10.1951 mL	20.3903 mL
5 mM	0.4078 mL	2.0390 mL	4.0781 mL
10 mM	0.2039 mL	1.0195 mL	2.0390 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶