Men 10376 TFA Neurokinin-2 receptor antagonist TFA|西域试剂

Men 10376 TFA Neurokinin-2 receptor antagonist TFA,99.56%

产品编号：Bellancom-P1276A| 分子式：C₅₉H₆₉F₃N₁₂O₁₂| 分子量：1195.25

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货号	价格	库存与货期
Bellancom-P1276A	￥1950.00	杭州北京（现货）
Bellancom-P1276A	￥6900.00	杭州北京（现货）
Bellancom-P1276A	￥11000.00	杭州北京（现货）

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Men 10376 TFA Neurokinin-2 receptor antagonist TFA

产品介绍

Men 10376 TFA 是一种有效的选择性的 tachykinin NK-2 受体拮抗剂，对大鼠小肠 NK-2 受体的 K_i 值为 4.4 μM。

生物活性

Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

体外研究

Men 10376 is a selective tachykinin NK-2 receptor, with a K_i of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (K_i, >10 μM). Men 10376 shows pA₂s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (K_i, >10 μM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 1.43 mg/mL (1.20 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8366 mL	4.1832 mL	8.3665 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light