STING agonist-3 trihydrochloride
| 产品介绍 | STING agonist-3 trihydrochloride 源于专利 WO2017175147A1 (实施例10)，是一种选择性和非核苷酸的小分子 STING 激动剂，pEC50 和 pIC50 分别为 7.5 和 9.5。STING agonist-3 trihydrochloride 具有持久的抗肿瘤作用，并且在改善癌症研究方面具有巨大潜力。 |
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| 生物活性 | STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
| 体外研究 |
STING agonist-3 trihydrochloride exhibits a pEC50 value of 7.5 in activation of STING in cells, this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter. STING agonist-3 trihydrochloride exhibits a pIC50 value of 9.5 in FRET assay. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 | |
| 体内研究 | |
| 性状 | Solid |
| 溶解性数据 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
| 参考文献 |
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