MitoCur-1|西域试剂

MitoCur-1,95.0%

产品编号：Bellancom-150228| 分子式：C₆₅H₆₄Cl₂O₆P₂| 分子量：1074.05

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-150228		￥7800.00	杭州北京（现货）

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MitoCur-1

产品介绍

MitoCur-1 是一种姜黄素类似物，是线粒体抗氧化硫氧还蛋白还原酶2(TrxR2) 的抑制剂。MitoCur-1 具有亲电性和线粒体靶向性。MitoCur-1 可诱导活性氧 (ROS) 的产生，具有特异性抗肿瘤作用。

生物活性

MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy.

体外研究

MitoCur-1对 HepG2 和 L02 细胞具有选择性细胞毒性，IC₅₀ 分别为 1.4 μM 和 9.1 μM。
MitoCur-1 (10 μM; 12 h) 在 HepG2 细胞中产生 ROS 并选择性地消耗 GSH。
MitoCur-1 (10 μM; 24 h) 阻滞 G0/G1 期细胞周期，抑制细胞周期蛋白表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HepG2 cells
Concentration:	2.5 μM, 5 μM, and 10 μM
Incubation Time:	24 h, 36 h, and 48 h
Result:	Decreased the protein level of CDK2 and CDK4, Cyclin E1/D1/A2.

Immunofluorescence

Cell Line:	HepG2 and L02 cells
Concentration:	10 μM
Incubation Time:	12 h
Result:	Showed selectivity on HepG2 cells over L02 cells to generates ROS. Promoted mitochondrial O₂^- production.

Cell Viability Assay

Cell Line:	HepG2 cells
Concentration:	1.25 μM, 2.5 μM, 5 μM, and 10 μM
Incubation Time:	48 h; pretreated with 400 μM DTT or not
Result:	Inhibited HepG2 cells viability. Showed significant reversion with DTT for 1 h pretreatment.

体内研究
(In Vivo)

MitoCur-1 (5 mg/kg，15 mg/kg；腹腔注射; 每隔天施用一次，共 4 周) 抑制小鼠模型肿瘤生长，对体重无影响。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice bearing HepG2 tumor
Dosage:	5 mg/kg, 15 mg/kg
Administration:	Intraperitoneal injection; every other day for 4 weeks
Result:	Decreased the tumor growth in vivo.

体内研究

MitoCur-1 (5 mg/kg，15 mg/kg；腹腔注射; 每隔天施用一次，共 4 周) 抑制小鼠模型肿瘤生长，对体重无影响。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice bearing HepG2 tumor
Dosage:	5 mg/kg, 15 mg/kg
Administration:	Intraperitoneal injection; every other day for 4 weeks
Result:	Decreased the tumor growth in vivo.

体内研究

MitoCur-1 (5 mg/kg，15 mg/kg；腹腔注射; 每隔天施用一次，共 4 周) 抑制小鼠模型肿瘤生长，对体重无影响。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice bearing HepG2 tumor
Dosage:	5 mg/kg, 15 mg/kg
Administration:	Intraperitoneal injection; every other day for 4 weeks
Result:	Decreased the tumor growth in vivo.