Abemaciclib metabolite M2-d<sub>6</sub> LSN2839567-d<sub>6</sub>|西域试剂

Abemaciclib metabolite M2-d₆ LSN2839567-d₆,99.25%

产品编号：Bellancom-128669S| 分子式：C₂₅H₂₂D₆F₂N₈| 分子量：484.58

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-128669S		￥17500.00	杭州北京（现货）

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Abemaciclib metabolite M2-d₆ LSN2839567-d₆

产品介绍

Abemaciclib metabolite M2-d₆ 是 Abemaciclib metabolite M2 的氘代物。Abemaciclib metabolite M2 (LSN2839567)是 Abemaciclib 的代谢物，为有效的 CDK4 和 CDK6 抑制剂，IC₅₀ 值为 1-3 nM。具有抗肿瘤活性。

生物活性

Abemaciclib metabolite M2-d₆ is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity.

体外研究

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 2.12 mg/mL (4.37 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0636 mL	10.3182 mL	20.6364 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献