RA375|西域试剂

RA375,99.31%

产品编号：Bellancom-136563| 分子式：C₃₀H₂₅ClN₄O₇| 分子量：589.00

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-136563	￥3500.00	杭州北京（现货）
Bellancom-136563	￥6000.00	杭州北京（现货）
Bellancom-136563	￥17000.00	杭州北京（现货）
Bellancom-136563	￥26000.00	杭州北京（现货）

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RA375

产品介绍

RA375 是 RPN13 (26S 蛋白酶体亚基) 抑制剂。RA375 激活 UPR 信号、ROS 产生和凋亡。RA375 的抗肿瘤活性是 RA190的 10 倍。

生物活性

RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.

体外研究

体内研究

RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.
Dosage:	10 mg/kg.
Administration:	IP for a 5 days on, 2 days off cycle for two weeks.
Result:	Reduced ovarian tumor burden in mice.

Animal Model:	Female Balb/c mice.
Dosage:	5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
Administration:	IP single dose.
Result:	The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.

体内研究

RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.
Dosage:	10 mg/kg.
Administration:	IP for a 5 days on, 2 days off cycle for two weeks.
Result:	Reduced ovarian tumor burden in mice.

Animal Model:	Female Balb/c mice.
Dosage:	5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
Administration:	IP single dose.
Result:	The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (169.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6978 mL	8.4890 mL	16.9779 mL
5 mM	0.3396 mL	1.6978 mL	3.3956 mL
10 mM	0.1698 mL	0.8489 mL	1.6978 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式