ZC0109|西域试剂

ZC0109,99.32%

产品编号：Bellancom-151978| 分子式：C₂₂H₂₀BrFN₈O₄S| 分子量：591.41

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-151978		￥5400.00	杭州北京（现货）
Bellancom-151978		￥8600.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

ZC0109

产品介绍

ZC0109 是 IDO1 和硫氧还蛋白还原酶 1 (TrxR1) 的双抑制剂，IC₅₀ 分别为 50 nM 和 3.0 μM。ZC0109 诱导活性氧 (ROS) 积累，使细胞周期阻滞于 G1/S 期，导致癌细胞凋亡 (apoptosis)。

生物活性

ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1) with IC₅₀s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis.

体外研究

ZC0109 (24 h) inhibits cancer cells with IC₅₀s of 3.44 μM (HCT-116), 12.4 μM (CT26), and 10.2 μM (HeLa), respectively.
ZC0109 (2.5-10 μM; 24 h) induces ROS accumulation in HCT-116 and HeLa cells.
ZC0109 (2.5-10 μM; 24 h) induces apoptosis and G1/S cell cycle arrest in cancer cell.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis

Cell Line:	HCT-116 cells and HeLa cells
Concentration:	2.5 μM, 5 μM, and 10 μM
Incubation Time:	24 hours
Result:	Arrested cell cycle at G1/S phase.

体内研究
(In Vivo)

ZC0109 (15, 30, and 60 mg/kg; p.o.; once daily for 28 d) reduces Kyn/Trp metabolism in C57BL/6 mice.
ZC0109 (60 mg/kg; p.o.; once daily for 28 d) decreases tumor growth and increases accumulation and infiltration of T cells in CT-26 cells transplanted immunocompetent BALB/c mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (84.54 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6909 mL	8.4544 mL	16.9087 mL
5 mM	0.3382 mL	1.6909 mL	3.3817 mL
10 mM	0.1691 mL	0.8454 mL	1.6909 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式