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内质网应激与UPR 

Endoplasmic reticulum (ER) stress occurs when the protein synthesis requirements of the cell exceed the protein folding capacity of the ER. Improperly folded proteins accumulate in the ER, which triggers the unfolded protein response (UPR) to restore ER homeostasis.
Following translation, secreted and transmembrane proteins enter the lumen of the endoplasmic reticulum (ER), where they are post-translationally modified and properly folded in the presence of specialized chaperone proteins. This process is overwhelmed during ER stress, which can be triggered by stimuli such as nutrient deprivation, infection, toxins or mutations in abundantly expressed proteins.
In severe cases, the accumulation of improperly folded proteins can cause cell death, so in order to relieve ER stress and restore ER homeostasis, the cell activates a series of signaling pathways, collectively called the unfolded protein response (UPR).

产品编号 分子式图片 CAS No. 名称及描述 规格 价格 快速订购
西域试剂-WR120715
1337531-36-8

GSK2606414, ≥99%

GSK2606414

5mg ¥1064.00 价格库存
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5mg ¥1064.00 现货 点击购买
25mg ¥2732.00 现货 点击购买
西域试剂-WR146582
877963-94-5

LOC-14, 99%

LOC-14

10mg ¥1377.00 价格库存
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10mg ¥1377.00 现货 点击购买
西域试剂-WR342147
932986-18-0

N-(2-(2-(4-氯苯基)噻唑-4-基)乙基)丁酰胺, 99%

Azoramide

25mg ¥240.00 价格库存
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25mg ¥240.00 现货 点击购买
100mg ¥656.00 现货 点击购买
西域试剂-WR349659
14003-96-4

4μ8C, 99.9%

4μ8C

5mg ¥133.00 价格库存
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5mg ¥133.00 现货 点击购买
25mg ¥400.00 现货 点击购买
100mg ¥1069.00 现货 点击购买
西域试剂-WR350021
1216665-49-4

APY29 , ≥99.9%

APY29 

10mg ¥1310.00 价格库存
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50mg ¥3328.00 现货 点击购买
西域试剂-WR350644
346640-08-2

CCF642, 98%

AC1LYELL

5mg ¥945.00 价格库存
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5mg ¥945.00 现货 点击购买
西域试剂-WR351812
1337532-29-2

GSK2656157, 99.9%

GSK2656157

10mg ¥1404.00 价格库存
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10mg ¥1404.00 现货 点击购买
西域试剂-WR352175
1597403-47-8

ISRIB (trans-isomer), >99%

ISRIB (trans-isomer)

10mg ¥538.00 价格库存
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10mg ¥538.00 现货 点击购买
50mg ¥1671.00 现货 点击购买

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