二氢黄酮甙|Hesperiden|cas:520-26-3|西域试剂

二氢黄酮甙,Hesperiden,≥80%

产品编号：SIGMA-H5254| CAS NO：520-26-3| 分子式：C28H34O15| 分子量：610.5606

Hesperidin (Hesperetin 7-rutinoside) 是一种广泛存在于柑橘类水果中黄烷酮糖苷。Hesperidin 具有多种生物学特性，例如减少炎症介质并发挥重要的抗氧化作用。Hesperidin 还表现出抗肿瘤和抗过敏活性。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
SIGMA-H5254		￥323.37	杭州北京（现货）
SIGMA-H5254		￥1,071.68	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

二氢黄酮甙

英文名称

Hesperiden

CAS编号

520-26-3

产品描述

产品熔点

250-255 °C (dec.)(lit.)

产品沸点

930.1±65.0 °C at 760 mmHg

产品密度

1.7±0.1 g/cm3

产品闪点

305.5±27.8 °C

精确质量

610.189758

PSA

234.29000

LogP

1.78

外观性状

白色至浅褐色粉末

蒸气压

0.0±0.3 mmHg at 25°C

折射率

1.695

溶解性

DMSO : ≥ 33 mg/mL (54.05 mM)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (163.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6378 mL	8.1892 mL	16.3784 mL
5 mM	0.3276 mL	1.6378 mL	3.2757 mL
10 mM	0.1638 mL	0.8189 mL	1.6378 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.09 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.09 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在西域网站选购。

体外研究

Hesperidin (5 -200 μM；24-72 h) 在人骨肉瘤 MG-63 细胞中诱导有效的细胞毒性作用。
Hesperidin (5-150 μM；48 h) 诱导早期和晚期细胞凋亡在 MG-63 细胞中。
Hesperidin (10-30 μM) 以剂量依赖的方式抑制 RAW 264.7 细胞中 COX-2 和 iNOS 的活性LPS。
Hesperidin (0.1 μg/mL；2 h) 减少 MDA 和细胞内 ROS 的形成，包括软骨细胞凋亡。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	MG-63 cells
Concentration:	0, 5, 25, 50, 100, 150, 200 µM
Incubation Time:	24, 48, 72 hours
Result:	Led to time-dependent and concentration-dependent cytotoxic effects, with IC₅₀s of 94.3, 78.6 and 63.3 µM at 24, 48 and 72 h, respectively.

Apoptosis Analysis

Cell Line:	MG-63 cells
Concentration:	0, 5, 50, 150 µM
Incubation Time:	48 hours
Result:	Increased the percentage of apoptotic cells from 4.7% to 17.9, 34.6 and 68.3% at the concentration of 0, 5, 50 and 150 µM, respectively.

体内研究

Hesperidin (5 -80 mg/kg；2 周) 显著抑制小鼠 MG-63 肿瘤的生长。
Hesperidin (200 mg/kg；每天一次，连续 28 天) 显著在手术诱发的骨关节炎 (OA) 大鼠中减轻软骨破坏并降低 IL-1β 和 TNF-α 水平。

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.6378 mL	8.1892 mL	16.3784 mL
5 mM	0.3276 mL	1.6378 mL	3.2757 mL
10 mM	0.1638 mL	0.8189 mL	1.6378 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

稳定性

淡黄色结晶性粉末。熔点258-262℃（252℃软化）。易溶于吡啶、氢氧化钠溶液，溶于二甲基甲酰胺，微溶于甲醇和热冰醋酸，极微溶于乙醚，丙酮、氯仿和苯。该品1g溶于50L水。无臭、无味。

储存条件

储存条件 2-8°C, protect from light, dry, sealed

冰袋运输根据产品的不同，可能会有相应调整。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R22
安全声明 (欧洲)	S22-S24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	MK6650000

1. 物质的识别

产品名：	Hesperidin
CAS号：	520-26-3
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Hesperidin
别名：	Hesperetin 7-rutinoside
分子式：	C28H34O15
分子量：	610.56

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

161713-86-6

520-26-3

文献：Yamada, Mika; Tanabe, Fujimi; Arai, Norie; Mitsuzumi, Hitoshi; Miwa, Yoshikatsu; Kubota, Michio; Chaen, Hiroto; Kibata, Masayoshi Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 6 p. 1386 - 1394

161713-86-6

520-26-3

520-33-2

64-17-5

50376-44-8

520-26-3

文献：Shimokoriyama Journal of the American Chemical Society, 1957 , vol. 79, p. 4199,4200

64726-90-5

369593-42-0

520-26-3

文献：Belboukhari, Nasser; Cheriti, Abdelkrim; Roussel, Christian; Vanthuyne, Nicolas Natural Product Research, 2010 , vol. 24, # 7 p. 669 - 681

上游产品 4
161713-86-6 64-17-5 50376-44-8 64726-90-5
下游产品 6
537-73-5 520-27-4 520-33-2 1356391-89-3
26184-96-3 187539-57-7

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二氢黄酮甙,Hesperiden,≥80%

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

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