壬酸 ,Nonanoic acid ,≥97%

产品编号:SIGMA-N5502| CAS NO:112-05-0| 分子式:C9H18O2| 分子量:158.24

Nonanoic acid 是一种天然存在的具有九个碳原子的饱和脂肪酸。Nonanoic acid 显着减少细菌易位,增强抗菌活性,并显着增加猪 β-防御素 1 (pBD-1) 和 pBD-2 的分泌。

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货号 包装 价格 库存与货期 购买量 操作
SIGMA-N5502
1393.00 杭州 北京(现货)
SIGMA-N5502
460.00 杭州 北京(现货)
SIGMA-N5502
1904.00 杭州 北京(现货)
SIGMA-N5502
455.00 杭州 北京(现货)
SIGMA-N5502
4122.00 杭州 北京(现货)

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产品名称 壬酸
英文名称Nonanoic acid
CAS编号112-05-0
产品描述Nonanoic acid 是一种天然存在的具有九个碳原子的饱和脂肪酸。Nonanoic acid 显着减少细菌易位,增强抗菌活性,并显着增加猪 β-防御素 1 (pBD-1) 和 pBD-2 的分泌。
产品熔点9 °C(lit.)
产品沸点268-269 °C(lit.)
产品密度0.906 g/mL at 25 °C(lit.)
产品闪点212 °F
精确质量158.13100
PSA37.30000
LogP2.82160
外观性状透明油性液体,带有一种不愉快的,腐臭的气味
蒸气压<0.1 mm Hg ( 20 °C)
折射率n20/D 1.432(lit.)
溶解性NEGLIGIBLE
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (631.95 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.3195 mL 31.5976 mL 63.1951 mL
5 mM 1.2639 mL 6.3195 mL 12.6390 mL
10 mM 0.6320 mL 3.1598 mL 6.3195 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (15.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (15.80 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液
  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (15.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (15.80 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (15.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (15.80 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在西域网站选购。
体外研究

壬酸通过组蛋白脱乙酰酶抑制上调内源性宿主防御肽增强肠上皮免疫屏障功能。

稳定性

1. 有腐蚀性。小鼠经口LD5015mg/kg。静脉注射LD50224mg/kg。操作人员应穿戴防护用具。

2. 存在于烤烟烟叶、白肋烟烟叶、香料烟烟叶、烟气中。

3. 天然存在于香蕉、啤酒、面包中。

4. 有强烈的刺激性。
 

储存条件1.储存于阴凉、通风的库房。远离火种、热源。防止阳光直射。保持容器密封。应与氧化剂、酸类分开存放,切忌混储。配备相应品种和数量的消 防器材。储区应备有泄漏应急处理设备和合适的收容材料。 2.工业品用塑料桶,每桶25kg。分析试剂用玻璃瓶装,每瓶500g。按一般化学品贮运。

相关文档

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

相关产品


符号 GHS05
GHS05
信号词 Danger
危害声明 H314
警示性声明 P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
个人防护装备 Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲) C:Corrosive;
风险声明 (欧洲) R34
安全声明 (欧洲) S26-S28-S36/37/39-S45-S28A
危险品运输编码 UN 3265 8/PG 3
WGK德国 1
RTECS号 RA6650000
包装等级 III
危险类别 8
海关编码 2915900090
Name: n-Nonanoic acid 97% Material Safety Data Sheet
Synonym: Pelargonic Acid
CAS: 112-05-0
Section 1 - Chemical Product MSDS Name:n-Nonanoic acid 97% Material Safety Data Sheet
Synonym:Pelargonic Acid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
112-05-0 n-Nonanoic acid 97% 203-931-2
Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.
Potential Health Effects
Eye:
Causes eye burns. Causes redness and pain.
Skin:
Causes skin burns. Causes redness and pain.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract.
Chronic:
Chronic exposure may cause effects similar to those of acute exposure.

Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 112-05-0: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Clear liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 254 deg C
Freezing/Melting Point: 12.5 deg C
Autoignition Temperature: Not available.
Flash Point: 114 deg C ( 237.20 deg F)
Explosion Limits, lower: 1.20
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 0.3g/l
Specific Gravity/Density: 0.900
Molecular Formula: C9H18O2
Molecular Weight: 158.1248

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not currently available.
Conditions to Avoid:
None reported.
Incompatibilities with Other Materials:
Bases, oxidizing agents, reducing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 112-05-0: RA6650000 LD50/LC50:
CAS# 112-05-0: Draize test, rabbit, eye: 91 mg Severe; Draize test, rabbit, eye: 100 uL Mild; Draize test, rabbit, skin: 500 mg/24H Moderate; Oral, mouse: LD50 = >5 gm/kg; Oral, rat: LD50 = >5 gm/kg; Skin, rat: LD50 = >2 gm/kg.
Carcinogenicity:
n-Nonanoic acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Pseudomonas putida:

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.*
Hazard Class: 8
UN Number: 3265
Packing Group: III
IMO
Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3265
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3265
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 112-05-0: No information available.
Canada
CAS# 112-05-0 is listed on Canada's DSL List.
CAS# 112-05-0 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 112-05-0 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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