阿魏酸|Ferulic acid (≥98%,HPLC)|cas:1135-24-6|西域试剂

阿魏酸,Ferulic acid (≥98%,HPLC)

产品编号：Bellancom-A1047| CAS NO：1135-24-6| MDL NO：Null,without related properties.| 分子式：C10H10O4| 分子量：194.187

Ferulic acid 是一种新型的成纤维细胞生长因子受体 1 (FGFR1) 抑制剂, 对于 FGFR1 和 FGFR2 的 IC50值分别为 3.78 and 12.5 μM。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-A1047		￥260.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

阿魏酸

英文名称

Ferulic acid (≥98%,HPLC)

CAS编号

1135-24-6

产品描述

Ferulic acid 是一种新型的成纤维细胞生长因子受体 1 (FGFR1) 抑制剂, 对于 FGFR1 和 FGFR2 的 IC50值分别为 3.78 and 12.5 μM。

产品熔点

168-172 °C(lit.)

产品沸点

372.3±27.0 °C at 760 mmHg

产品密度

1.3±0.1 g/cm3

产品闪点

150.5±17.2 °C

精确质量

194.057907

PSA

66.76000

LogP

1.64

外观性状

顺式异构体为黄色油状物。反式异构体为斜方针状结晶（水）。

蒸气压

0.0±0.9 mmHg at 25°C

折射率

1.627

溶解性

溶于DMSO，微溶于热水。

溶解性数据

In Vitro:

DMSO : 100 mg/mL (514.99 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.1499 mL	25.7493 mL	51.4986 mL
5 mM	1.0300 mL	5.1499 mL	10.2997 mL
10 mM	0.5150 mL	2.5749 mL	5.1499 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

靶点

IC50: 3.78 μM (FGFR1), 12.5 μM (FGFR2)

体外研究

阿魏酸（FA）是一种新型成纤维细胞生长因子受体1（FGFR1）抑制剂，FGFR1和FGFR2的IC50分别为3.78和12.5μM。阿魏酸对FGFR1表现出很强的抑制活性，在1μM时抑制率为92％。在阿魏酸处理5至40μM，持续24小时后，FGF1刺激的HUVEC增殖显着降低。阿魏酸在高达20μM时不会发挥显着的细胞活力，但超过30μM阿魏酸与对照相比在HUVEC中表现出细胞毒性作用。阿魏酸以剂量依赖性方式抑制FGF1诱导的HUVEC迁移和侵袭。阿魏酸显着抑制FGF1诱导的PI3K和Akt的磷酸化。阿魏酸处理显着抑制FGF1刺激的MMP-2和MMP-9表达。

体内研究

用阿魏酸（FA）治疗有效抑制FGF1诱导的新血管形成。发现与用DMSO处理的对应物相比，胃酸给予阿魏酸显着抑制肿瘤体积和肿瘤重量。此外，阿魏酸治疗耐受性良好，载体组和FA治疗组之间的体重没有显着差异。通过口服途径给予的阿魏酸（0.01,0.1,1或10mg / kg）显着降低了强迫游泳试验（FST）和尾部悬吊试验（TST）中的不动时间，而在开放场试验中没有产生影响。结果表明阿魏酸（0.001 mg / kg，po）的施用增强了氟西汀（5 mg / kg，po）在TST中的抗抑郁样作用。

细胞实验

将HUVEC（5×10 4个细胞/孔）接种到凝胶化的24孔培养板上，并在含有15％FBS的ECGS中培养。用DMSO（0.1％）或不同浓度的阿魏酸（FA）（0,2.5,5,10,20,30,40μM）处理HUVEC 24小时。通过MTT测定确定细胞活力。孵育4小时后，用酶标仪在450nm处测量吸光度。结果由每个实验的六个重复计算。进行了三次独立实验。

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.1499 mL	25.7493 mL	51.4986 mL
5 mM	1.03 mL	5.1499 mL	10.2997 mL
10 mM	0.515 mL	2.5749 mL	5.1499 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

稳定性

1. 如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物。

2. 存在于烤烟烟叶、烟气中。

储存条件

储存条件 2-8°C, protect from light, dry, sealed

运输方式冰袋运输，根据产品的不同，可能会有相应调整

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
危害码 (欧洲)	Xi:Irritant
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S36-S37/39
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	UD3365500
海关编码	1302199099

1. 物质的识别

产品名：	Ferulic Acid
CAS号：	1135-24-6
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Ferulic Acid
别名：	Coniferic acid
分子式：	C10H10O4
分子量：	194.18

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	2-8°C, sealed

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 8
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