4-羟基苯甲酸异丁酯|Isobutyl 4-hydroxybenzoate|cas:4247-02-3|西域试剂

4-羟基苯甲酸异丁酯,Isobutyl 4-hydroxybenzoate,97%

产品编号：Sigma-715077| CAS NO：4247-02-3| MDL NO：MFCD00020167| 分子式：C11H14O3| 分子量：194.23

Isobutylparaben (Isobutyl 4-hydroxybenzoate) 是组成型雄烷受体 (CAR) 激活剂。Isobutylparaben 具有广谱抗菌 (antimicrobial) 活性，并广泛用于个人护理产品和化妆品中。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Sigma-715077	￥540.00	杭州北京（现货）
Sigma-715077	￥1135.00	杭州北京（现货）
Sigma-715077	￥2250.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

4-羟基苯甲酸异丁酯

英文名称

Isobutyl 4-hydroxybenzoate

CAS编号

4247-02-3

产品描述

Isobutylparaben (Isobutyl 4-hydroxybenzoate) 是组成型雄烷受体 (CAR) 激活剂。Isobutylparaben 具有广谱抗菌 (antimicrobial) 活性，并广泛用于个人护理产品和化妆品中。

产品熔点

76°C

产品沸点

302.3±15.0 °C at 760 mmHg

产品密度

1.1±0.1 g/cm3

产品闪点

125.4±13.2 °C

精确质量

194.094299

PSA

46.53000

LogP

3.28

外观性状

白色奶油色

蒸气压

0.0±0.7 mmHg at 25°C

折射率

1.524

溶解性

可溶于：甲醇

溶解性数据

In Vitro:

DMSO : 100 mg/mL (514.85 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.1485 mL	25.7427 mL	51.4854 mL
5 mM	1.0297 mL	5.1485 mL	10.2971 mL
10 mM	0.5149 mL	2.5743 mL	5.1485 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

稳定性

常温常压下稳定，无色细小晶体或白色结晶性粉末。无臭。难溶于水(0.035g/100ml，25℃)。易溶于乙醇、冰醋酸、丙二醇和丙酮。

储存条件

避光，通风干燥处，密封保存

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

相关产品

符号	GHS07, GHS09
信号词	Warning
危害声明	H315-H319-H411
警示性声明	P305 + P351 + P338
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	51/53
安全声明 (欧洲)	S22-S24/25
危险品运输编码	UN 3077 9/PG 3
RTECS号	DH2247000
海关编码	2918290000

Section I.Chemical Product and Company Identification
Chemical Name Isobutyl 4-Hydroxybenzoate
Portland OR
Synonym4-Hydroxybenzoic Acid Isobutyl Ester;
Isobutylparaben
Chemical FormulaC11H14O3

CAS Number4247-02-3

Section II.Composition and Information on Ingredients
Toxicology Data
Chemical NameCAS Number Percent (%)TLV/PEL
Min. 99.0 (T) Not available.Not available.
Isobutyl 4-Hydroxybenzoate4247-02-3

Section III. Hazards Identification
Acute Health EffectsIrritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

Section IV.First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact
minutes. Get medical attention.
In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
Skin Contact
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
InhalationIf the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
IngestionINDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.

Section V.Fire and Explosion Data
Not available.
May be combustible at high temperature.Auto-Ignition
Flammability
Flammable LimitsNot available.
Flash PointsNot available.
Combustion ProductsThese products are toxic carbon oxides (CO, CO2).
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Isobutyl 4-Hydroxybenzoate

Section VI.Accidental Release Measures
Spill CleanupIrritating material. Skin sensitizing material.
Use a shovel to put the material into a convenient waste disposal container. Consult federal, state, and/or local authorities for
Instructions
assistance on disposal.

Section VII. Handling and Storage
Handling and StorageIRRITANT. SKIN SENSITIZER. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the
container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe dust.
Information

Section VIII. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
Engineering Controls
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
Personal Protection
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsNot available.

Section IX. Physical and Chemical Properties
Physical state @ 20°CSolid. (Crystal, powder. Whtie - almostSolubility
Soluble in methanol;
white.)
Very soluble in ethanol, ether, acetone;
Very slightly soluble in water.
Not available.
Specific Gravity
Molecular Weight194.23Partition CoefficientLOG Pow: 3.11
Boiling PointNot available.Vapor PressureNot applicable.
Melting Point76°C (168.8°F)Vapor DensityNot available.
Not available.Not available.
Refractive IndexVolatility
Critical TemperatureNot available.OdorNot available.
Not available.Not available.
ViscosityTaste

Section X.Stability and Reactivity Data
Stability

This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of InstabilityAvoid excessive heat and light.
IncompatibilitiesReactive with strong oxidizing agents.

Section XI. Toxicological Information
RTECS NumberDH2247000
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Not available.
Toxicity Data
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
Acute Toxic Effects
is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Section XII.Ecological Information
Not available.
Ecotoxicity
Environmental FateNot available.
Continued on Next Page
Isobutyl 4-Hydroxybenzoate

Section XIII. Disposal Considerations
Waste DisposalRecycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
Not a DOT controlled material (United States).
DOT Classification
PIN NumberNot applicable.
Proper Shipping NameNot applicable.
Packing Group (PG)Not applicable.
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationOn DSL.
(Canada)
EINECS Number (EEC) 224-208-8
EEC Risk StatementsR36/37/38- Irritating to eyes, respiratory system and skin.
R43- May cause sensitization by skin contact.

SECTION 16 - ADDITIONAL INFORMATION
N/A