黄芩苷|Baicalin (≥98%,HPLC)|cas:21967-41-9|西域试剂

黄芩苷,Baicalin (≥98%,HPLC)

产品编号：Bellancom-A1016| CAS NO：21967-41-9| MDL NO：Null,without related properties.| 分子式：C21H18O11| 分子量：446.36732

Baicalin（黄芩苷）可以通过抑制oncomiRNAs的表达，从而诱导结肠癌细胞凋亡（apoptosis）。同时能通过抑制肝细胞癌细胞中PD-L1的表达，促进抗肿瘤免疫。此外，Baicalin还可以激活肝脏CPT1，改善饮食引起的肥胖和肝脏脂肪变性。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-A1016		￥290.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

黄芩苷

英文名称

Baicalin (≥98%,HPLC)

CAS编号

21967-41-9

产品描述

产品熔点

202-205 ºC

产品沸点

836.6±65.0 °C at 760 mmHg

产品密度

1.7±0.1 g/cm3

产品闪点

297.2±27.8 °C

精确质量

446.084900

PSA

187.12000

LogP

0.31

外观性状

淡黄色结晶粉末

蒸气压

0.0±3.2 mmHg at 25°C

折射率

1.740

溶解性

DMSO : ≥ 100 mg/mL (224.03 mM)；H2O : 0.1 mg/mL (0.22 mM; Need ultrasonic)

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (224.03 mM)

H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2403 mL	11.2017 mL	22.4034 mL
5 mM	0.4481 mL	2.2403 mL	4.4807 mL
10 mM	0.2240 mL	1.1202 mL	2.2403 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 0.5% CMC-Na/saline water
Solubility: 20 mg/mL (44.81 mM); Suspended solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.60 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.60 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在西域网站选购。

靶点

NF-κB

Autophagy

体外研究

黄芩苷通过改变各种介质的产生来保护缺血再灌注损伤（IRI），包括活性氧（ROS），Toll样受体（TLR）2和TLR4，NF-κB，Bax和Bcl-2。黄芩苷处理抑制促炎细胞因子TLR2 / 4，MyD88，p-NF-κB和p-IκB的表达增加，以及增加NF-κB抑制剂IκB蛋白的表达，与抑制程度呈正相关以黄芩苷的剂量。通过MTT测定确定细胞活力。与对照细胞相比，用凝血酶处理的SH-SY5Y细胞的细胞活力显着降低。与单独处理凝血酶的细胞相比，用黄芩苷（5,10,20μM）预处理以剂量依赖性方式增加细胞活力。

体内研究

黄芩苷预处理剂量依赖性地防止肾功能丧失，两种较高剂量（10和100mg / kg）显着降低Scr和血尿素氮（BUN）浓度。使用0-3点评分系统评估的组织损伤对于黄芩苷处理组而言低于缺血再灌注（IR）+盐水组。与假手术组相比，10和100 mg / kg黄芩苷处理的大鼠丙二醛（MDA）含量仅略有上调，SOD活性仅略有下调，表明黄芩苷可消除再灌注后氧化应激的增加。

细胞实验

将SH-SY5Y细胞系在补充有15％胎牛血清的RPMI-1640培养基中于37℃在含有95％空气和5％CO 2和饱和湿度的空气气氛中培养。在60~70％的汇合时，将SH-SY5Y细胞分成：（i）对照组，在RPMI-1640培养基中培养; （ii）凝血酶组，根据我们的预实验，其受凝血酶诱导（40U / L）6小时; （iii）黄芩苷基团，其在诱导凝血酶之前用黄芩苷（5μM，10μM或20μM）处理2小时。使用MTT测定法测量细胞活力。简而言之，向每个孔中加入15μLMTT溶液（5mg / mL）并在37℃下孵育4小时。除去上清液后，向各孔中加入80μLDMSO。使用酶标仪在492nm处测量吸光度。所有实验一式三份进行。

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.2403 mL	11.2017 mL	22.4034 mL
5 mM	0.4481 mL	2.2403 mL	4.4807 mL
10 mM	0.224 mL	1.1202 mL	2.2403 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

稳定性

Baicalin（黄芩苷）可以通过抑制oncomiRNAs的表达，从而诱导结肠癌细胞凋亡（apoptosis）。同时能通过抑制肝细胞癌细胞中PD-L1的表达，促进抗肿瘤免疫。此外，Baicalin还是一种变构肉碱棕榈酰转移酶1 (CPT1)的激活剂,可以激活肝脏CPT1，改善饮食引起的肥胖和肝脏脂肪变性。Baicalin黄芩苷促进Fe(2+)电子向溶解氧的转移。黄芩苷对lps诱导的IEC-6细胞和细胞间紧密连接有保护作用。其机制可能与抑制炎症细胞因子的产生、上调ZO-1的mRNA和蛋白表达有关。黄芩苷对大鼠体内咖啡因及其代谢产物的药代动力学无明显影响。Baicalin作为一种类黄酮糖苷，它降低 NF-κB 表达的作用可能是通过抑制HBE16气道上皮细胞NF-κB信号通路而抑制IL-6、IL-8和TNF-α的表达。

储存条件

密封保存。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P305 + P351 + P338
危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	LZ5776910

1. 物质的识别

产品名：	Baicalin
CAS号：	21967-41-9
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Baicalin
别名：	Baicalein 7-O-β-D-glucuronide; 5, 6-dihydroxy-7-O-glucuronide flavone
分子式：	C21H18O11
分子量：	446.36

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 8
67047-05-6 67047-06-7 491-67-8 2616-64-0
74304-67-9 57820-69-6 67047-07-8 1178862-93-5
下游产品 4
491-67-8 35990-03-5 36948-76-2 1180-46-7

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