人参皂苷Rb2|Ginsenoside Rb2 (≥98%,HPLC)|cas:11021-13-9|西域试剂

人参皂苷Rb2,Ginsenoside Rb2 (≥98%,HPLC)

产品编号：Bellancom-A1228| CAS NO：11021-13-9| MDL NO：Null,without related properties.| 分子式：C53H90O22| 分子量：1079.27

Ginsenoside Rb2 是人参提取物的主要生物活性成分之一。Ginsenoside Rb2 可以上调 GPR120 基因表达。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-A1228		￥830.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

人参皂苷Rb2

英文名称

Ginsenoside Rb2 (≥98%,HPLC)

CAS编号

11021-13-9

产品描述

Ginsenoside Rb2 是人参提取物的主要生物活性成分之一。Ginsenoside Rb2 可以上调 GPR120 基因表达。

产品熔点

197-199ºC

产品沸点

1117.1±65.0 °C at 760 mmHg

产品密度

1.4±0.1 g/cm3

产品闪点

629.4±34.3 °C

精确质量

1078.592407

PSA

357.06000

LogP

4.73

外观性状

白色粉末（乙醇-丁醇1:5）

蒸气压

0.0±0.6 mmHg at 25°C

折射率

1.622

溶解性

Soluble in H2O，DMSO。

溶解性数据

In Vitro:

H₂O : ≥ 100 mg/mL (92.66 mM)

DMSO : 9.5 mg/mL (8.80 mM; Need ultrasonic and warming)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9266 mL	4.6328 mL	9.2655 mL
5 mM	0.1853 mL	0.9266 mL	1.8531 mL
10 mM	0.0927 mL	0.4633 mL	0.9266 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (92.66 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 0.92 mg/mL (0.85 mM); Clear solution

此方案可获得 ≥ 0.92 mg/mL (0.85 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 9.2 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 0.92 mg/mL (0.85 mM); Clear solution

此方案可获得 ≥ 0.92 mg/mL (0.85 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 9.2 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 0.92 mg/mL (0.85 mM); Clear solution

此方案可获得 ≥ 0.92 mg/mL (0.85 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 9.2 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

靶点

GPR120

体外研究

人参皂苷Rb2预处理增强了α-亚麻酸（ALA）的抗炎作用，并且增强作用严格依赖于GPR120活化。人参皂苷Rb2通过增加GPR120表达并随后增强ω-3脂肪酸诱导的GPR120活化，在体外对脂多糖（LPS）刺激的小鼠巨噬细胞RAW264.7细胞发挥抗炎作用。人参皂苷Rb2通过激活AMPK改善肝细胞中的葡萄糖代谢，并通过减少氧化损伤降低3T3-L1细胞中的胆固醇和三酰基甘油水平。人参皂甙Rb2在鼠骨髓间充质干细胞（BMMSCs）中发挥抗凋亡作用。 MTT测定结果显示，在不存在或存在ALA的情况下，人参皂甙Rb2（高达100μM）对RAW264.7细胞没有明显的细胞毒性。通过用人参皂苷Rb2（0.1-100μM）处理细胞12小时，然后收获和裂解，研究Rb2对RAW264.7巨噬细胞中GPR120表达的影响。随后的Western印迹分析显示GPR120的表达通过人参皂甙Rb2剂量依赖性地上调。实时PCR结果表明RAW264.7巨噬细胞与人参皂苷Rb2（10μM）孵育12小时导致GPR120 mRNA表达增加2.8倍。此外，由人参皂甙Rb2刺激的GPR120表达的这种增加是时间依赖性的并且早在6小时开始。这些结果表明Rb2在RAW264.7巨噬细胞中以剂量和时间依赖性方式上调GPR120表达。

体内研究

人参皂苷Rb2是一种抗病毒试剂，可以预防轮状病毒（RV）感染。当在病毒攻击前3天，2天或1天施用各种剂量的人参皂甙Rb2（25至250mg / kg）时，在病毒感染前3天以75mg / kg的剂量用该人参皂甙处理最有效地减少轮状病毒（RV）诱发腹泻。此外，在病毒感染前3天，2天和1天连续施用人参皂甙Rb2（75mg / kg）比在第3天单次施用更有效。连续施用人参皂甙Rb2还可降低RV感染小鼠肠道中的病毒滴度。

细胞实验

使用MTT测定法测定细胞活力。将RAW264.7细胞（2×10 4个细胞/孔）接种在96孔板中并在生长培养基中培养过夜。然后在加入MTT试剂（0.5mg / mL）之前，在不存在或存在ALA的情况下将细胞与指定浓度的人参皂苷Rb2（0.1,1,10和100μM）一起温育48小时。温育4小时后，除去培养基，形成的甲crystals晶体用100μLDMSO溶解。使用FlexStation 3 测量波长为492 nm的吸光度。

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.9266 mL	4.6328 mL	9.2655 mL
5 mM	0.1853 mL	0.9266 mL	1.8531 mL
10 mM	0.0927 mL	0.4633 mL	0.9266 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

储存条件

储存条件: 2-8°C

运输方式: 冰袋运输，根据产品的不同，可能会有相应调整。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

风险声明 (欧洲)	R22
安全声明 (欧洲)	45
危险品运输编码	NONH for all modes of transport
RTECS号	LZ5779240

1. 物质的识别

产品名：	Ginsenoside-Rb2
CAS号：	11021-13-9
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Ginsenoside-Rb2
别名：	Ginsenoside C
分子式：	C53H90O22
分子量：	1079.27

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	4°C, protect from light, dry, sealed

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

1346522-90-4

11021-13-9

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