[Pro9]-Substance P|cas:104486-69-3|西域试剂

[Pro9]-Substance P

产品编号：西域质检-YEP2475| CAS NO：104486-69-3| 分子式：C66H102N18O13S| 分子量：1387.69

[Pro9]-P物质是NK-1速激肽受体的有效、可逆和选择性激动剂，EC50为0.93 nM。

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货号	包装	价格	库存与货期	购买量	操作
西域质检-YEP2475		￥680.00	杭州北京（现货）
西域质检-YEP2475		￥1350.00	杭州北京（现货）

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产品名称

[Pro9]-Substance P

CAS编号

104486-69-3

产品描述

[Pro9]-P物质是NK-1速激肽受体的有效、可逆和选择性激动剂，EC50为0.93 nM。

产品密度

1.43g/cm3

精确质量

1386.76000

PSA

533.14000

LogP

4.61590

折射率

1.669

溶解性数据

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

靶点

NK1:0.93 nM (EC50)

体外研究

[3H][Pro9]-P物质可以用作NK-1结合位点的放射配体。[Pro9]-P物质刺激磷酸肌醇的形成，其效力仅略低于SP（EC50值分别为0.93±0.07和0.45±0.06 nM）对新生小鼠皮层神经胶质细胞的原代培养。

储存条件

储存条件: -20°C

运输方式: 冰袋运输，根据产品的不同，可能会有相应调整。

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