桔霉素,Citrinin,分析标准品,≥99%(HPLC)

产品编号:西域质检-TM20578| CAS NO:518-75-2| 分子式:C13H14O5| 分子量:250.25

Citrinin 是一种引起食品污染的真菌毒素,具有不同的毒性作用。Citrinin 通常与另一种肾毒性真菌毒素 Ochratoxin A 一起发现。Citrinin 据报道在体外具有广泛的生物活性,包括抗菌、抗真菌和潜在的抗癌和神经保护作用。

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货号 包装 价格 库存与货期 购买量 操作
西域质检-TM20578
850.00 杭州 北京(现货)

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桔霉素

本标准物质的研制、生产和定值依据ISO/IEC 17025, ISO 17034和ISO 9001质量认证管理体系。 主要用于确保质量控制过程中样品测试的量值准确性,亦可用于测量仪器校准、分析方法确认与评价、操作人员水平考核等。

一、样品制备

桔霉素在适宜培养基产生并经制备液相分离纯化得到,样品纯度初检合格后,分装到洁净的棕色玻璃瓶中。
 桔霉素,英文名称:Citrinin,分子式:C13H14O5,分子量:250.25,CAS No.:518-75-2

二、溯源性及定值方法

本标准物质以配制值作为标准值,通过使用满足计量学特性要求的制备方法,测量方法和计量器具,保证标准物质的量值溯源性。

三、特性量值及不确定度
编号 名称 浓度(%) 相对扩展不确定度(%)(k=2)
714182-1mg 桔霉素 99.1 0.9

标准值的不确定度综合考虑了原料纯度定值结果,制备过程,量值核验以及均匀性,稳定性等引入的不确定度分量。

四、均匀性检验及稳定性考察

依据JJF1343-2022《标准物质的定值及均匀性、稳定性评估》,对分装后的样品进行随机抽样,对溶液浓度进行均匀性检验,稳定性考察。结果表明,本标准物质均匀性,稳定性良好。
 本标准物质量值自定值日期起,有效期33个月, 研制单位将继续跟踪监测该标准物质的稳定性,有效期内如发现量值变化,将及时通知用户。

五、包装、运输和贮存、使用及注意事项

1、包装: 本固体纯度标准物质采用棕色玻璃瓶包装,1mg/瓶。
 2、贮存:运输时应避免挤压,碰撞;常温(20±5)℃,置于阴凉处贮存。
 3、使用:使用前,将样品放在干燥器中干燥2小时,平衡至室温后再进行使用。

六、安全警示

本溶液物质属于有毒有害物质,在操作过程中请戴口罩、手套在通风橱中操作,避免吸入或皮肤接触。本标准物质仅限实验室使用,不可食用。

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符号 GHS02 GHS07
GHS02, GHS07
信号词 Danger
危害声明 H225-H302-H312-H319-H332
警示性声明 P210-P280-P305 + P351 + P338
个人防护装备 Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) T
风险声明 (欧洲) 23/24/25-40-36/37/38
安全声明 (欧洲) S26-S36/37/39-S45
危险品运输编码 UN 3462 6.1/PG 3
WGK德国 3
RTECS号 DJ2275000
包装等级 II
危险类别 6.1(a)
Name: Citrinin Material Safety Data Sheet
Synonym: None
CAS: 518-75-2
Section 1 - Chemical Product MSDS Name:Citrinin Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
518-75-2 Citrinin ca.100 208-257-2
Hazard Symbols: T
Risk Phrases: 23/24/25

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed.Cancer suspect agent.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed.
Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Hormones and antibiotics room.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 518-75-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C13H14O5
Molecular Weight: 250.25

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stability unknown.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 518-75-2: DJ2275000 LD50/LC50:
CAS# 518-75-2: Oral, mouse: LD50 = 105 mg/kg; Oral, rabbit: LD50 = 134 mg/kg.
Carcinogenicity:
Citrinin - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: II
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: II
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: II

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 518-75-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 518-75-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 518-75-2 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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文献:Warren et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 3422 Full Text View citing articles Show Details Schwenk; Schubert; Stahl Archives of Biochemistry, 1949 , vol. 20, p. 220,226

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文献:Roedel, Thomas; Gerlach, Hans Liebigs Annalen, 1995 , # 5 p. 885 - 888
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文献:Johnson et al. Journal of the Chemical Society, 1950 , p. 2971,2973

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文献:Asano et al. Yakugaku Zasshi, 1951 , vol. 71, p. 268,270 Chem.Abstr., 1952 , p. 485

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文献:Cartwright; Robertson; Whalley Journal of the Chemical Society, 1949 , p. 1563,1566

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文献:Wang; Ting Science Record (Peking), 1951 , vol. 4, p. 269,270

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文献:Cartwright; Robertson; Whalley Journal of the Chemical Society, 1949 , p. 1563,1566
  • 5. Zhen, Z.; Xiong, X.; Liu, Y.; Zhang, J.; Wang, S.; Li, L.; Gao, M. NaCl Inhibits Citrinin and Stimulates Monascus Pigments and Monacolin K Production. Toxins 2019, 11, 118. https://doi.org/10.3390/toxins11020118
  • 4. Xiong, Xiaoqian, et al. "Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na+ Concentration of Intracellular and Extracellular Monascus purpureus." Bioelectromagnetics 41.4 (2020): 289-297.https://doi.org/10
  • 3. 胡佳莉. 红曲黄精发酵工艺及免疫调节和降血脂作用研究[D].广东药科大学,2020.
  • 2. 周珂, 严鹏程, 胡永丹. 高产橙黄色素低产桔霉素红曲菌的液态发酵条件优化[J]. 食品与发酵工业, 2020, 046(007):116-122.
  • 1. 庄晓晓 王钰 李阔阔 等. 低产桔霉素红曲霉复合诱变育种[J]. 生物学杂志 2018 35(001):104-106 124.

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