天然产物/莫诺苷|cas:25406-64-8|西域试剂

天然产物/莫诺苷,≥98%

产品编号：西域质检-TM48436| CAS NO：25406-64-8| 分子式：C₁₇H₂₆O₁₁| 分子量：406.382

Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用。

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货号	包装	价格	库存与货期	购买量	操作
西域质检-TM48436		￥262.00	杭州北京（现货）

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天然产物/莫诺苷

Reference Material

This certificate is designed in accordance with ISO 17034 and ISO Guide 31. This reference material (RM) was designed,produced and verified in accordance with ISO/IEC 17025, ISO 17034 and a registered quality management system ISO 9001.

Product Name(产品名称) Morroniside

Product Code(产品编号) 723921-20mg

Lot Number(产品批号) -

CAS No. 25406-64-8

Mol. Weight(分子量) 406.38

Mol. Formula(分子式) C₁₇H₂₆O₁₁

Melting Point(熔点) N/A

Expiry Date(失效日期) -

Boiling point(沸点) N/A

Appearance(外观) White to Off-White Solid

Storage Temp(存储条件) (2~8)℃,Keep in the shade

C E R T I F I E D

Purity

99.6%

C E R T I F I E D

Expanded Uncertainty (U)

0.8%

Uncertainty

The certified value(s) and uncertainty(ies) are determined in accordance with ISO 17034 with an 95% confidence level(k=2). Uncertainty is based on the Total Combined Uncertainty, including uncertainties of characterisation, homogeneity and stability testing. Stability values are based on real evidence opposed to simulation.

Traceability

The balances used for gravimetric measurements are calibrated with weights traceable to the national standards. The calibration of the balances is verified annually by an external accredited calibration service. This analysis method has been verified using an approach consistent with ISO 17034:2016 & ISO 17025:2017.

CERTIFICATE ON	QC SIGNATURE
-		RM Release

Method of Identification

HPLC

Method of Identification

HPLC

Intended Use

This RM is intended for use in a laboratory as a calibration and quality control standard or in method development for analytical techniques.

Storage

This reference material meets the specification stated in this certificate until the expiry date, provided it is stored unopened at the recommended temperature here in. If storage after opening is necessary, the RM should be tightly closed and kept from light and moisture.

Hazards

Read Material Safety Data Sheet (MSDS) and understand any potential hazard(s) prior to the use of this product. All chemicals should be considered potentially hazardous in nature and should only be handled by qualified personnel using established good laboratory practices.

Homogeneity

Random replicate samples of the final packaged RM have been analysed to prove homogeneity compliant with ISO 17034.

Instructions for use

It is recommended to use 1 mg as the minimum sample size and if less material is used, to increase the certified uncertainty by a factor of two for half sample and four for a quarter of sample.Visit the support section of our website technology videos and frequently asked questions.

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

1. 物质的识别

产品名：	Morroniside
CAS号：	25406-64-8
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Morroniside
分子式：	C17H26O11
分子量：	406.38

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

33. [7.425] Xiaoya Sun et al."Characterization and identification of chemical constituents in Corni Fructus and effect of storage using UHPLC-LTQ-Orbitrap-MS."FOOD RESEARCH INTERNATIONAL.2022 Dec;:112330

32. [IF=3.693] Li Cao et al."Cornus officinalis vinegar reduces body weight and attenuates hepatic steatosis in mouse model of nonalcoholic fatty liver disease."JOURNAL OF FOOD SCIENCE

31. [IF=3.935] Yi-Jie Qian et al."Quality evaluation of raw and processed Corni Fructus by UHPLC-QTOF-MS and HPLC coupled with color determination."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 Sep;218:114842

30. [IF=6.53] Pan Sun et al."Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis."BIOMEDICINE & PHARMACOTHERAPY. 2022 Jun;150:112975

29. [IF=3] Hui-Qin PAN et al."Plant metabolomics for studying the effect of two insecticides on comprehensive constituents of Lonicerae Japonicae Flos."Chin J Nat Medicines. 2021 Jan;19:70

28. [IF=3.935] Hengqiang Zhao et al."An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicerae Japonicae."J Pharmaceut Biomed. 2019 Oct;175:112758

27. [IF=4.225] Xue Gao et al."Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro."Front Pharmacol. 2020; 11: 533809

26. [IF=4.451] Xiao Han et al."An iridoid glycoside from Cornus officinalis balances intestinal microbiome disorder and alleviates alcohol-induced liver injury."J Funct Foods. 2021 Jul;82:104488

25. [IF=5.396] Binkai Han et al."Ultrasound-assisted enzymatic extraction of Corni Fructus alpha-glucosidase inhibitors improves insulin resistance in HepG2 cells."Food Funct. 2021 Oct;12(20):9808-9819

24. [IF=4.142] Ji Wenhua et al."Superhydrophilic molecularly imprinted polymers based on a single cross-linking monomer for the recognition of iridoid glycosides in Di-huang pills."Anal Bioanal Chem. 2018 Oct;410(25):6539-6548

23. [IF=4.174] Lv Gaohong et al."Effect of morroniside on glomerular mesangial cells through AGE–RAGE pathway."Hum Cell. 2016 Oct;29(4):148-154

22. [IF=4.472] Yang Cui-cui et al."Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration."J Alzheimers Dis. 2016 Jan;51(1):33-44

21. [IF=4.759] Wenhua Ji et al."Water-compatible micron-sized monodisperse molecularly imprinted beads for selective extraction of five iridoid glycosides from Cornus officinalis fructus."J Chromatogr A. 2017 Jun;1504:1

20. Hengqiang Zhao, Changjiangsheng Lai, Minmin Zhang, Siduo Zhou, Qian Liu, Daijie Wang, Yanling Geng, Xiao Wang, An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicera

19. Hengqiang Zhao, Changjiangsheng Lai, Minmin Zhang, Siduo Zhou, Qian Liu, Daijie Wang, Yanling Geng, Xiao Wang, An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicera

18. Lv, Gaohong, et al. "Effect of morroniside on glomerular mesangial cells through AGE–RAGE pathway." Human cell 29.4 (2016): 148-154.https://doi.org/10.1007/s13577-015-0128-0

17. Gao, X., Liu, Y., Wang, L., Sai, N., Liu, Y., & Ni, J. (2020). Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro. Frontiers in pharmacology, 11, 533809. https://doi.org/10.3389/fphar.20

16. Xiao Han, Jia Liu, Yingfeng Bai, Aiwu Hang, Tulin Lu, Chunqin Mao, An iridoid glycoside from Cornus officinalis balances intestinal microbiome disorder and alleviates alcohol-induced liver injury, Journal of Functional Foods, Volume 82, 2021, 104488, ISSN

15. 王明洋,牛红妹,张丽,李雅莉,李林,张兰.莫诺苷对大鼠原代皮层神经元氧糖剥夺模型线粒体质量控制体系的影响[J].中国药理学通报,2020,36(09):1221-1227.

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12. 陶玉菡,许惠琴,李莉,农伟虎,李伟.生地、山茱萸抑制和清除糖基化产物的效应成分研究[J].中药药理与临床,2013,29(04):30-33.

11. 韩根利刘宏胜王树森等. RP-HPLC法同时测定山茱萸萜类制剂中莫诺苷马钱苷山茱萸新苷齐墩果酸及熊果酸[J]. 中草药 2017 48(024):5168-5173.

10. 白昱旸, 陈强, 梁丽娜,等. 祛风及开窍类引经药对六味地黄丸有效成分眼内分布的影响[J]. 中国中医眼科杂志, 2017.

9. 刘凯, 许惠琴, 吴佳蕾,等. 马钱苷、莫诺苷对AGEs损伤HUVEC的增殖的影响[J]. 中药药理与临床, 2014, 030(003):53-57.

8. 李富欣, 于蓓蓓, 刘瑾,等. 茯黄颗粒的质量标准研究[J]. 西部中医药, 2019, 032(002):P.44-48.

7. 苏艳莹, 雷小小, 桂卉,等. 星点设计-效应面法优化山茱萸总环烯醚萜苷脂质体的制备工艺[J]. 中国药房, 2018, 29(19):25-29.

6. 刘芳, 武勇. 山茱萸果实生物量积累及莫诺苷,马钱苷含量的动态变化研究[J]. 长治医学院学报, 2020(3):169-172.

5. 邹恺平, 王鹏, 刘顺,等. 雅致小克银汉霉对莫诺苷生物转化工艺的研究[J]. 中南药学, 2020年18卷6期, 942-947页, ISTIC CA, 2020.

4. 周玉燕, 孙玉, 李萍,等. 莫诺苷通过抗氧化应激保护雷公藤甲素所致肝细胞凋亡[J]. 南方医科大学学报, 2018, 038(008):949-955.

3. 白玉杰, 唐世琪, 武留信,等. 莫诺苷对大鼠心肌缺血再灌注损伤的保护作用及可能机制[J]. 中华全科医学, 2017, 09(v.17):18-20.

2. 周清, 侯峰, 董斌,等. 用超高速液相色谱法同时测定山茱萸药材中马钱苷和莫诺苷的含量[J]. 药学服务与研究, 2012, 12(006):441,446,457.

1. 鲁静, 陈天朝, 马彦江,等. 炮制对山茱萸有效成分含量的影响[J]. 中医药信息, 2020, v.37;No.212(02):49-52.