梓醇|cas:2415-24-9|西域试剂

梓醇,分析标准品,HPLC≥99%

产品编号：西域质检-TM59075| CAS NO：2415-24-9| 分子式：C₁₅H₂₂O₁₀| 分子量：362.329

Catalpol (Catalpinoside)，是一种在 Rehmannia glutinosa 中发现的鸢尾花苷，具有神经保护，降血糖，抗炎，抗癌，抗痉挛，抗氧化和抗 HBV 的作用。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
西域质检-TM59075		￥400.00	杭州北京（现货）
西域质检-TM59075		￥750.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

梓醇

Reference Material

This certificate is designed in accordance with ISO 17034 and ISO Guide 31. This reference material (RM) was designed,produced and verified in accordance with ISO/IEC 17025, ISO 17034 and a registered quality management system ISO 9001.

Product Name(产品名称) Catalpol(梓醇)

Product Code(产品编号) 723891-20mg

Lot Number(产品批号) -

CAS No. 2415-24-9

Mol. Weight(分子量) 362.33

Mol. Formula(分子式) C₁₅H₂₂O₁₀

Melting Point(熔点) N/A

Expiry Date(失效日期) -

Boiling point(沸点) N/A

Appearance(外观) White to Off-White Solid
(白色固体)

Storage Temp(存储条件) (2~8)℃,dark
冷藏(2~8)℃避光

C E R T I F I E D

Purity

99.9%

C E R T I F I E D

Expanded Uncertainty (U)

0.8%

Uncertainty

The certified value(s) and uncertainty(ies) are determined in accordance with ISO 17034 with an 95% confidence level(k=2). Uncertainty is based on the Total Combined Uncertainty, including uncertainties of characterisation, homogeneity and stability testing. Stability values are based on real evidence opposed to simulation.

Traceability

The balances used for gravimetric measurements are calibrated with weights traceable to the national standards. The calibration of the balances is verified annually by an external accredited calibration service. This analysis method has been verified using an approach consistent with ISO 17034:2016 & ISO 17025:2017.

CERTIFICATE ON	QC SIGNATURE
-		RM Release

Method of Identification

HPLC

Method of Identification

HPLC

Intended Use

This RM is intended for use in a laboratory as a calibration and quality control standard or in method development for analytical techniques.

Storage

This reference material meets the specification stated in this certificate until the expiry date, provided it is stored unopened at the recommended temperature here in. If storage after opening is necessary, the RM should be tightly closed and kept from light and moisture.

Hazards

Read Material Safety Data Sheet (MSDS) and understand any potential hazard(s) prior to the use of this product. All chemicals should be considered potentially hazardous in nature and should only be handled by qualified personnel using established good laboratory practices.

Homogeneity

Random replicate samples of the final packaged RM have been analysed to prove homogeneity compliant with ISO 17034.

Instructions for use

It is recommended to use 1 mg as the minimum sample size and if less material is used, to increase the certified uncertainty by a factor of two for half sample and four for a quarter of sample.Visit the support section of our website technology videos and frequently asked questions.

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26
危险品运输编码	NONH for all modes of transport
RTECS号	LZ5776816

1. 物质的识别

产品名：	Catalpol
CAS号：	2415-24-9
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Catalpol
别名：	Catalpinoside
分子式：	C15H22O10
分子量：	362.33

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

81720-06-1

2415-24-9

文献：Oshio,H.; Inouye,H. Phytochemistry (Elsevier), 1982 , vol. 21, p. 133

6910-20-9

81892-75-3

2415-24-9

文献：Phytochemistry (Elsevier), , vol. 21, p. 231

75598-56-0

121-34-6

2415-24-9

文献：Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 5 p. 1023 - 1025

1374308-81-2

93-07-2

2415-24-9

文献：Helvetica Chimica Acta, , vol. 95, # 4 p. 586 - 593

上游产品 4
81720-06-1 6910-20-9 75598-56-0 1374308-81-2
下游产品 0

36. [2.65] Minghui Wu et al."Catalpol Regulates Oligodendrocyte Regeneration and Remyelination by Activating the GEF-Cdc42/Rac1 Signaling Pathway in EAE Mice."Evidence-based Complementary and Alternative Medicine.2022 Nov 25;2022:7074157

35. [IF=3.978] Du Jikun et al."Catalpol Ameliorates Neurotoxicity in N2a/APP695swe Cells and APP/PS1 Transgenic Mice."NEUROTOXICITY RESEARCH.2022 Jun;:1-12

34. [IF=2.759] Yuxi Di et al."Catalpol Inhibits Tregs-to-Th17 Cell Transdifferentiation by Up-Regulating Let-7g-5p to Reduce STAT3 Protein Levels."Yonsei Med J. 2022 Jan; 63(1): 56–65

33. [IF=1.982] Lili Song et al."Metabolism of Du Zhong Formula in rats using UPLC-Q-TOF/MS."J Mass Spectrom. 2022 Jan;57(1):e4795

32. [IF=2.984] Linluo Zhang et al."Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway."Peerj. 2022 Jan;10:e12759

31. [IF=3.935] Yong-Sheng Wu et al."Chemical profiling of Callicarpa nudiflora and its effective compounds identification by compound-target network analysis."J Pharmaceut Biomed. 2020 Apr;182:113110

30. [IF=4.162] Weixin Hou et al."The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats."Drug Des Dev Ther. 2021; 15: 3845–3862

29. [IF=4.183] Wan Gong et al."Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats."Int J Mol Sci. 2019 Jan;20(16

28. [IF=4.225] Yang Fan et al."Catalpol Protects Against Pulmonary Fibrosis Through Inhibiting TGF-β1/Smad3 and Wnt/β-Catenin Signaling Pathways."Front Pharmacol. 2021 Jan;11:2472

27. [IF=4.225] Yang Chunjing et al."Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms."Front Pharmacol. 2020 May;11:690

26. [IF=4.36] Chenglin Song et al."Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis."J Ethnopharmacol. 2021 Dec;281:114571

25. [IF=6.6] Longtai You et al."Catalpol Protects ARPE-19 Cells against Oxidative Stress via Activation of the Keap1/Nrf2/ARE Pathway."Cells-Basel. 2021 Oct;10(10):2635

24. [IF=2.1] Yun Han et al."Antiangiogenic effects of catalpol on rat corneal neovascularization."Mol Med Rep. 2018 Feb;17(2):2187-2194

23. [IF=2.479] Yang Tao et al."Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice."Bmc Complem Altern M. 2017 Dec;17(1):1-15

22. [IF=4.411] Dan-Dan Tian et al."Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats."Molecules. 2016 Jun;21(6):696

21. [IF=4.411] Wei Wang et al."In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism."Molecules. 2016 May;21(5):597

20. [IF=4.545] Chao Lin et al."Catalpol protects glucose-deprived rat embryonic cardiac cells by inducing mitophagy and modulating estrogen receptor."Biomed Pharmacother. 2017 May;89:973

19. [IF=4.759] Mingzhen He et al."Application of characteristic ion filtering with ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry for rapid detection and identification of chemical profiling in Eucommia ulmoides Oliv."J C

18. [IF=6.799] Yun Tang et al."Quantifying orientational regeneration of injured neurons by natural product concentration gradients in a 3D microfluidic device."Lab Chip. 2018 Mar;18(6):971-978

17. Wang, Wei, Dan-Dan Tian, and Zhang-Jin Zhang. "In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism." Molecules 21.5 (2016): 597.https://doi.org/10.3390/molecules21050597

16. He, Mingzhen, et al. "Application of characteristic ion filtering with ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry for rapid detection and identification of chemical profiling in Eucommia ulmoides Oliv."

15. Lin, Chao, et al. "Catalpol protects glucose-deprived rat embryonic cardiac cells by inducing mitophagy and modulating estrogen receptor." Biomedicine & Pharmacotherapy 89 (2017): 973-982.https://doi.org/10.1016/j.biopha.2017.02.069

14. Yang, Tao, et al. "Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice." BMC complementary and alternative medicine 17.1 (2017): 1-15.https://doi.org/10.1186/s12906-017

13. Yang, Chunjing, et al. "Neuroprotective effect of catalpol via anti-oxidative, anti-inflammatory, and anti-apoptotic mechanisms." Frontiers in Pharmacology 11 (2020): 690.https://doi.org/10.3389/fphar.2020.00690

12. 化宝军,赵世莉,苏妍妍,杨椹.梓醇对急性肾损伤大鼠TLR4/NF-κB通路及肾小球内皮损伤的影响[J].中国中西医结合肾病杂志,2020,21(12):1042-1046+1137.

11. 李尽文,宋代博,李苑华,麦键城,刘咏倩,李莉.梓醇对宫颈癌HeLa细胞增殖及凋亡作用的研究[J].山东化工,2020,49(17):43-45.

10. 陶玉菡,许惠琴,李莉,农伟虎,李伟.生地、山茱萸抑制和清除糖基化产物的效应成分研究[J].中药药理与临床,2013,29(04):30-33.

9. 周炳文, 钟晓明, 黄真. 玄参环烯醚萜苷热回流提取工艺的优化[J]. 中成药, 2018, 040(006):1292-1297.

8. 蒙雄裕, 徐良, 李华强,等. 用RP-HPLC法测定天目地黄中梓醇和毛蕊花糖苷的含量[J]. 药学服务与研究, 2015, 15(004):273-276.

7. 陆春红, 许惠琴, 刘凯,等. 生地环烯醚萜苷类成分对AGEs损伤HUVEC的保护作用[J]. 南京中医药大学学报, 2015, 31(001):55-59.

6. 李强, 胡晶红, 张永清,等. 晒干与烘干生地黄产量和质量比较[J]. 山东中医杂志, 2013(09):58-59+77.

5. 王素云, 卢颖, 蔡丹凤,等. 基于雌激素受体探讨梓醇对抗糖剥夺心肌细胞损伤的作用[J]. 中国药理学通报, 2019.

4. 和大奎, 朱文学, 于斌,等. 地黄浸膏超声真空干燥特性和动力学研究[J]. 江苏农业科学, 2017, 45(013):157-164.

3. 李民,辛杰,王春艳,李民,张淹.地黄中梓醇含量与产区相关性研究[J].中国药物评价,2014,31(04):212-214.

2. 张路王春艳李士栋等. 响应面设计优化地黄中梓醇的提取工艺研究[J]. 中国药物评价 2015 000(001):12-16.

1. 周霞张文倩刘炬李丽刘付红刘炳男.从血管内皮生长因子及其受体调控角度探讨地黄梓醇促血管新生作用及分子机制研究[J].实用心脑肺血管病杂志 2020 28(02):64-68.

梓醇,分析标准品,HPLC≥99%

梓醇

化学品安全说明书(MSDS)

质检证书(COA)

1. 物质的识别

2. 合成/成分数据

3. 急救措施

4. 消防措施

5. 泄漏应急处理

6. 处理和储存

7. 接触控制和个人防护

8. 稳定性和反应活性

9. 毒性资料

10. 生态资料

11. 废弃处置

12. 运输信息

13. 法规信息

14. 其他信息

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