异绿原酸C|Isochlorogenic acid C|cas:32451-88-0|西域试剂

异绿原酸C,Isochlorogenic acid C,分析标准品,HPLC≥99%

产品编号：Bellancom-YE28160| CAS NO：32451-88-0| 分子式：C₂₅H₂₄O₁₂| 分子量：516.46

4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种抗氧化剂，可从 Gynura divaricata 和 Laggera alata 中分离获得。4,5-Dicaffeoylquinic acid 能减少 2 型糖尿病小鼠胰岛细胞凋亡 (apoptosis)，改善胰腺功能，对酵母 α-葡萄糖苷酶 (α-glucosidase) 有明显的抑制活性。4,5-Dicaffeoylquinic acid 通过阻滞细胞周期来抑制前列腺癌细胞增殖。4,5-Dicaffeoylquinic acid 还具有抗凋亡、抗损伤和抗乙型肝炎病毒 (HBV)的作用。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-YE28160		￥1180.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

异绿原酸C

英文名称

Isochlorogenic acid C

CAS编号

32451-88-0

产品描述

产品沸点

810.8±65.0 °C at 760 mmHg

产品密度

1.6±0.1 g/cm3

产品闪点

274.9±27.8 °C

精确质量

516.126770

PSA

211.28000

LogP

0.89

外观性状

白色针晶粉末

蒸气压

0.0±3.0 mmHg at 25°C

折射率

1.719

溶解性

可溶于水，易溶于热水、甲醇、乙醇、丙酮等亲水性溶剂，微溶于乙酸乙酯，难溶于乙醚、氯仿、苯等亲脂性有机溶剂。

溶解性数据

In Vitro:

DMSO : 50 mg/mL (96.81 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9363 mL	9.6815 mL	19.3630 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
此方案可获得 ≥ 2.5 mg/mL (4.84 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.
请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
此方案可获得 ≥ 2.5 mg/mL (4.84 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
3.
请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
此方案可获得 ≥ 2.5 mg/mL (4.84 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

体外研究

4,5-Dicaffeoylquinic acid (0.1~100 µM; 72 h) has dose-dependent inhibitory activity against DU-145 prostate cancer cells, and induces cell cycle arrest, also induces inactivation of Bcl-2.
4,5-Dicaffeoylquinic acid (1~100 µg/mL; 48 h) has anti-apoptotic effect in D-GalN-challenged HL-7702 hepatocytes, and improves significantly cell viability at concentrations of 10 to 100 µg/mL.
4,5-Dicaffeoylquinic acid (1~100 µg/mL; 4 days) inhibits significantly expressions of HBsAg and HBeAg, and produces the maximum inhibition rates of 86.93 and 59.79% at 100 µg/mL on expressions of HBsAg and HBeAg, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	DU-145 cells
Concentration:	0.1~100 µM
Incubation Time:	72 h
Result:	Exhibits dose-dependent inhibitory activity against DU-145 prostate cancer cells with an IC₅₀ of 5 µM.

Cell Cycle Analysis

Cell Line:	DU-145 cells
Concentration:	5 µM
Incubation Time:	72 h
Result:	Decreased in numbers in G0/G1 phase and increased in S phase.

Apoptosis Analysis

Cell Line:	HL-7702 hepatocytes (exposure to 60 mM D-GalN for 6h)
Concentration:	1~100 μg/mL
Incubation Time:	48 h
Result:	Significantly reduced the caspase-3 and transforming growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes at 10~100 µg/mL.

Cell Viability Assay

Cell Line:	HL-7702 hepatocytes (exposure to 80 mM D-GalN for 6h)
Concentration:	1~100 μg/mL
Incubation Time:	48 h
Result:	Improved significantly cell viability at concentrations of 10 to 100 µg/mL, and produced a maximum protection rate of 47.28% at 100 µg/mL.

体内研究

4,5-Dicaffeoylquinic acid enhances the expression of GLUT2, GK, and PDX-1 protein, and effectively alleviate glycaemia and insulin resistance and enhance insulin sensitivity in type 2 diabetic mice.

Bellancom has not independently confirmed the accuracy of these methods. They are for reference only.

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-36/37/39

1. 物质的识别

产品名：	Isochlorogenic-acid-C
CAS号：	32451-88-0
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Isochlorogenic-acid-C
分子式：
分子量：

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

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