S07-2010
产品编号：Bellancom-150644| CAS NO：1223194-71-5| 分子式：C19H21N3O3S| 分子量：371.45
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S07-2010
| 产品介绍 | S07-2010 是一种有效的泛 AKR1C (醛缩酮还原酶家族 1 成员 C) 抑制剂，其对 AKR1C3、AKR1C4、AKR1C1 和 AKR1C2 的 IC50 分别为 0.19、0.36、0.47 和 0.73 μM。S07-2010 可诱导 A549/DDP 细胞凋亡 (apoptosis)。S07-2010 增强了化疗活性分子对耐药细胞的细胞毒性。S07-2010 对耐药细胞增殖有明显抑制作用。 |
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| 生物活性 | S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells. |
| 体外研究 |
S07-2010 (0-25 μM, 48h) exhibits obvious cytotoxicity on MCF-7/DOX and A549/DDP, with IC50 values of 127.5 and 5.51 μM, respectively. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 | |
| 体内研究 | |
| 性状 | |
| 溶解性数据 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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