Astaxanthin 虾青素,98.0%

产品编号:Bellancom-B2163| CAS NO:472-61-7| 分子式:C40H52O4| 分子量:596.84

Astaxanthin,一种红色的膳食类胡萝卜素,可从雨生红球藻 (Haematococcus pluvialis) 等多种海洋生物中提取得到,是过氧化物酶体增殖物活化受体γ (PPARγ) 的抑制剂,是具有抗增殖、神经保护作用和抗炎活性的有效抗氧化剂,可用于治疗多种疾病,如癌症和心血管疾病。因其鲜红的色泽,可用于动物饲料的着色剂。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用,

货号 包装 价格 库存与货期 购买量 操作
Bellancom-B2163
500.00 杭州 北京(现货)
Bellancom-B2163
700.00 杭州 北京(现货)

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Astaxanthin 虾青素

产品介绍 Astaxanthin,红色膳食类胡萝卜素,是一种口服有效的强效抗氧化剂。Astaxanthin 可抑制 NF-κB,能在蛋白质水平下调高血糖中的 VEGF。Astaxanthin 通过激活 PPARγ 并减少 STAT3 和相关通路蛋白的表达,发挥抗癌细胞增殖、增加凋亡以及削弱迁移和侵袭的活性。Astaxanthin 还具有神经保护和抗炎活性可用于癌症,糖尿病视网膜病变,心血管疾病等研究以及动物饲料的着色。
生物活性

Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[4][5].

体外研究

Astaxanthin (50, 100, 150, 200 µM; 48 h) inhibits the proliferation of DU145 cells (IC50<200 µM).
Astaxanthin (200 µM; 24 h) reduces the expression of STAT3 and the related pathway proteins (at both protein and mRNA levels) by inhibiting proliferation, increasing apoptosis and weakening migration and invasion
Astaxanthin protects RPE cells from abnormal activation and oxidative stress (induced by high glucose) by down-regulating VEGF in high glucose at protein levels.
Astaxanthin (1-50 µM; 72 h) upregulates protein expression of PPARγ in time- and dose-dependent manners in K562 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line: DU145 cells
Concentration: 200 µM (pre-incubation)
Incubation Time: 24 h
Result: Increased the percentage of apoptotic cells from 8.5% to 13.1% (compared to blank control).

Cell Migration Assay

Cell Line: DU145 cells
Concentration: 200 µM
Incubation Time: 24 h
Result: Decreased the migration and invasion of DU145 cells (about 41% of cells could not pass from one chamber to another, and 36% cells could not pass through the transwell membrane as compared to the control group).

Cell Proliferation Assay

Cell Line: ARPE-19 cells
Concentration: 50 µM (pre-incubation)
Incubation Time: 7 days
Result: Significantly decreased cell proliferation exposed to high glucose.

Western Blot Analysis

Cell Line: DU145 cells
Concentration: 200 µM
Incubation Time: 24 h
Result: Reduced the expression of STAT3 at both protein and mRNA levels (downregulated the protein expression of JAK2, BCL-2 and NF-κB and upregulated the protein expression of BAX, Caspase3 and Caspase9).

Western Blot Analysis

Cell Line: K562 cells
Concentration: 1-50 µM
Incubation Time: 72 h
Result: Significantly promoted PPARγ protein expression in time- and dose-dependent manners.
体内研究
(In Vivo)

Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice.
Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (approximately 20 g; DU145 tumor xenografts model).
Dosage: 200 mg/kg
Administration: Intragastric administration; once daily for 3 weeks.
Result: Exerted a significant inhibitory effect on tumor growth.
Animal Model: Female C57BL/6 mice (7 weeks old)[4].
Dosage: 125 or 500 mg/kg
Administration: In animal feedings; 7 days.
Result: Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.
Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively.
Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
体内研究

Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice.
Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (approximately 20 g; DU145 tumor xenografts model).
Dosage: 200 mg/kg
Administration: Intragastric administration; once daily for 3 weeks.
Result: Exerted a significant inhibitory effect on tumor growth.
Animal Model: Female C57BL/6 mice (7 weeks old)[4].
Dosage: 125 or 500 mg/kg
Administration: In animal feedings; 7 days.
Result: Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.
Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively.
Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
体内研究

Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice.
Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (approximately 20 g; DU145 tumor xenografts model).
Dosage: 200 mg/kg
Administration: Intragastric administration; once daily for 3 weeks.
Result: Exerted a significant inhibitory effect on tumor growth.
Animal Model: Female C57BL/6 mice (7 weeks old)[4].
Dosage: 125 or 500 mg/kg
Administration: In animal feedings; 7 days.
Result: Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.
Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively.
Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
性状Solid
溶解性数据
In Vitro: 

DMSO : 2 mg/mL (3.35 mM; Need ultrasonic)

Acetone : < 1 mg/mL (insoluble)

*Astaxanthin is usually formulated as a suspension.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6755 mL 8.3775 mL 16.7549 mL
5 mM --- --- ---
10 mM --- --- ---
*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 0.5% CMC-Na/saline water

    Solubility: 3.33 mg/mL (5.58 mM); Suspended solution; Need ultrasonic and warming

  • 2.

    请依序添加每种溶剂: 20% HP-β-CD in saline

    Solubility: 3.33 mg/mL (5.58 mM); Suspended solution; Need ultrasonic and warming

*以上所有助溶剂都可在 西域 网站选购。
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

参考文献

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1. 物质的识别
产品名: Astaxanthin
CAS号: 472-61-7
制造商/供应商: 西域试剂
网站:www.hzbp.cn   邮件:13911702513@139.com
2. 合成/成分数据
产品名: Astaxanthin
分子式: C40H52O4
分子量: 596.84
3. 急救措施
吸入后: 如果吸入,移至空气新鲜处,如果呼吸困难,给输氧,如呼吸停止,给予人工呼吸。
皮肤接触后: 用大量的水冲洗,移除污染的衣服和鞋子。
眼睛接触后: 检查并取下隐形眼镜,并用大量的水冲洗;呼叫医生。
吞食后: 如果吞食,用大量纯净水漱口;呼叫医生。
4. 消防措施
适当的灭火剂: 雾状水,二氧化碳,干粉或泡沫。
防护设备: 穿戴自给式呼吸器和防护服,以防止与皮肤和眼睛接触。
5. 泄漏应急处理
安全防范措施: 封锁泄漏区域;穿戴自给式呼吸器,防护服和厚橡胶手套。
清洁/收集措施: 使用液体粘合原料(硅藻土,通用粘合剂)吸取精细粉末;
使用酒精擦洗表面和设备除去污渍;
根据第11条处理被污染的材料。
6. 处理和储存
安全处理说明: 避免吸入和接触皮肤,眼睛及衣物;材料可能略微具有刺激性。
储存: -20°C, protect from light, dry, sealed
7. 接触控制和个人防护
呼吸设备: NIOSH / MSHA认可的呼吸器。
双手保护: 耐化学腐蚀的橡胶手套。
眼睛防护: 化学安全护目镜。
8. 稳定性和反应活性
稳定性: 按照说明存储是稳定的;避免强氧化剂。
热分解/其他要避免的情况: 避免光和热。
9. 毒性资料
急性毒性: 无可用资料。
主要刺激性影响: 无可用资料。
在皮肤上: 无可用资料。
对眼睛: 无可用资料;可能具有刺激性。
10. 生态资料
一般注意事项: 无可用资料。
11. 废弃处置
按照所在国家,省份,县市和地方的法规处置。
12. 运输信息
正确的运输名称:
非危险品运输: 这种物质被视为非危险品运输。
13. 法规信息
尚未有针对此产品作出的化学安全性评估。
14. 其他信息
这种化学品仅供受过训练的,有经验的研究人员在穿戴适当装备和授权允许的情况下进行操作处理。以上信息基于我们目前的知识被认为是正确的,但只适用于作为有经验人员的指导。请咨询您自己的安全顾问,并遵守当地和国家的安全法规。在任何其他没有被警告的情况下,并不意味着绝对没有危险存在。西域生物技术不承担任何使用这种化学品所造成的损害和责任。2023 西域生物技术版权所有。





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472-61-7结构式

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文献:WO2006/39685 A2, ; Page/Page column 58 ;

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472-61-7结构式

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文献:Journal of the Chemical Society. Perkin transactions 1, , # 21 p. 2195 - 2204
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