CRA-026440 hydrochloride|cas:847459-98-7|西域试剂

CRA-026440 hydrochloride,98.14%

产品编号：Bellancom-19754A| CAS NO：847459-98-7| 分子式：C₂₃H₂₅ClN₄O₄| 分子量：456.92

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-19754A		￥6100.00	杭州北京（现货）
Bellancom-19754A		￥9500.00	杭州北京（现货）

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CRA-026440 hydrochloride

产品介绍

CRA-026440 hydrochloride 是一种有效的广谱 HDAC (HDAC) 抑制剂。作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10 的 K_i 分别为 4 nM，14 nM，11 nM，15 nM，7 nM 和 20 nM。CRA-026440 hydrochloride 具有抗肿瘤和抗血管生成活性。

生物活性

CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The K_i values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities.

体外研究

CRA-026440 hydrochloride 对 HUVEC 内皮细胞具有抗增殖作用，GI₅₀ 值为 1.41 μM。
CRA-026440 hydrochloride（0.1-10 μM；18 小时）导致乙酰化组蛋白和乙酰化微管蛋白的积累，从而抑制肿瘤细胞生长并诱导细胞凋亡。
CRA-026440 hydrochloride（0.1-10 μM；5 天）以剂量依赖性方式抑制离体血管生成。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HCT116 cells
Concentration:	0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM
Incubation Time:	18 hours
Result:	Resulted in the accumulation of both acetylated histones and acetylated tubulin. Induced expression of the cyclin-dependent kinase inhibitor p21Cip1/WAF1.

体内研究
(In Vivo)

CRA-026440 hydrochloride（100 mg/kg；静脉注射；每天；连续三天）导致携带 HCT116 或 U937 人肿瘤异种移植物的小鼠肿瘤生长显着减少。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HCT-116 tumor-bearing nude mice
Dosage:	100 mg/kg
Administration:	i.v.; daily; for three consecutive days
Result:	Resulted in a statistically significant reduction in tumor growth.

体内研究

CRA-026440 hydrochloride（100 mg/kg；静脉注射；每天；连续三天）导致携带 HCT116 或 U937 人肿瘤异种移植物的小鼠肿瘤生长显着减少。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HCT-116 tumor-bearing nude mice
Dosage:	100 mg/kg
Administration:	i.v.; daily; for three consecutive days
Result:	Resulted in a statistically significant reduction in tumor growth.

体内研究

CRA-026440 hydrochloride（100 mg/kg；静脉注射；每天；连续三天）导致携带 HCT116 或 U937 人肿瘤异种移植物的小鼠肿瘤生长显着减少。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HCT-116 tumor-bearing nude mice
Dosage:	100 mg/kg
Administration:	i.v.; daily; for three consecutive days
Result:	Resulted in a statistically significant reduction in tumor growth.