BMH-21|cas:896705-16-1|西域试剂

BMH-21,98.80%

产品编号：Bellancom-12484| CAS NO：896705-16-1| 分子式：C₂₁H₂₀N₄O₂| 分子量：360.41

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货号	价格	库存与货期
Bellancom-12484	￥650.00	杭州北京（现货）
Bellancom-12484	￥2000.00	杭州北京（现货）
Bellancom-12484	￥3500.00	杭州北京（现货）
Bellancom-12484	￥12000.00	杭州北京（现货）

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BMH-21

产品介绍

BMH-21是一种首创的 DNA 嵌入剂 (DNA intercalator)，可抑制 RNA 聚合酶 I (Pol I) 转录。BMH-21 具有抗癌活性。

生物活性

BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity.

体外研究

BMH-21 binds ribosomal DNA and inhibits Pol I transcription.
BMH-21 inhibits RNA polymerase I independent of DNA damage response.
BMH-21 intercalates into double strand (ds) DNA and has binding preference towards GC-rich DNA sequences.
BMH-21 (1 μM; 3 hours) acts in a DNA damage independent manner to activate nucleolar stress and RPA194 degradation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	U2OS cells
Concentration:	0 μM, 0.1 μM , 1 μM, 10 μM
Incubation Time:	48 hours
Result:	Decreased the viability of cells at concentrations that activated the DNA damage response.

Western Blot Analysis

Cell Line:	A375 cells
Concentration:	1 μM
Incubation Time:	3 hours
Result:	Degraded RPA194 with blocked ATM and DNA-PK_cs activity.

体内研究
(In Vivo)

BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, daily, for 6 days
Result:	Significantly inhibited HCT116 colon cancer tumor growth.

体内研究

BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, daily, for 6 days
Result:	Significantly inhibited HCT116 colon cancer tumor growth.

体内研究

BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, daily, for 6 days
Result:	Significantly inhibited HCT116 colon cancer tumor growth.

性状

Solid

溶解性数据

In Vitro:

DMSO : 1 mg/mL (2.77 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7746 mL	13.8731 mL	27.7462 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式