8-Epixanthatin,99.51%
产品编号：Bellancom-137974| CAS NO：30890-35-8| 分子式：C15H18O3| 分子量：246.30
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8-Epixanthatin
| 产品介绍 | 8-Epixanthatin 是一种潜在的秋水仙碱结合位点抑制剂，从Xanthium chinese Mill 中分离得到。8-Epixanthatin 可以抑制 STAT3 的激活，诱导细胞凋亡( apoptosis)，具有抗肿瘤活性。 | ||||||||
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| 生物活性 | 8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity. | ||||||||
| 体外研究 |
8-Epixanthatin(2-20 μM, 12 h) 可以以剂量依赖性方式抑制 DU145 细胞增殖和 DU145 细胞的 p-STAT3 水平，其 IC50 值为 3.2 μM。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay
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| 体内研究 (In Vivo) |
8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) 在 DU145 细胞的小鼠异种移植模型中，可以通过 STAT3 失活抑制肿瘤生长，小鼠肿瘤体积减少了40.1%，肿瘤重量减少了40.0%，肿瘤中 p-STAT3 水平显著降低。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) 在 DU145 细胞的小鼠异种移植模型中，可以通过 STAT3 失活抑制肿瘤生长，小鼠肿瘤体积减少了40.1%，肿瘤重量减少了40.0%，肿瘤中 p-STAT3 水平显著降低。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) 在 DU145 细胞的小鼠异种移植模型中，可以通过 STAT3 失活抑制肿瘤生长，小鼠肿瘤体积减少了40.1%，肿瘤重量减少了40.0%，肿瘤中 p-STAT3 水平显著降低。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 性状 | Solid | ||||||||
| 溶解性数据 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||
| 参考文献 |
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