Epimedokoreanin B 朝藿素B|cas:161068-53-7|西域试剂

Epimedokoreanin B 朝藿素B

产品编号：Bellancom-N3831| CAS NO：161068-53-7| 分子式：C₂₅H₂₆O₆| 分子量：422.47

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Bellancom-N3831		￥2400.00	杭州北京（现货）

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Epimedokoreanin B 朝藿素B

产品介绍

Epimedokoreanin B 是一种天然黄酮类化合物，具有抗癌、抗炎和抗菌作用。Epimedokoreanin B 通过内质网应激介导的伴随自噬体积聚的细胞凋亡 (apoptosis) 抑制肺癌细胞的生长。Epimedokoreanin B 是一种抗牙周炎剂，可抑制牙龈蛋白酶和牙龈卟啉单胞菌的生长和生物膜形成。

生物活性

Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.

体外研究

Epimedokoreanin B (compound6; 3.13-25 μM; 48 hours) 对肺癌细胞 A549、Calu1 和 H1299 的增殖显示出显着的抑制作用。Epimedokoreanin B 对人支气管上皮细胞 BEAS-2B 无毒性。
Epimedokoreanin B 处理抑制 A549 和 NCI-H292 细胞中伴随细胞质空泡形成的细胞增殖和迁移。Epimedokoreanin B 处理的细胞中观察到自噬体聚集并伴有自噬通量阻断，这与内质网应激的发生相符。
Epimedokoreanin B（5 μM；24 小时）抑制 CD163 表达和 IL-10 的产生，这是已知的 M2 标记，表明 Epimedokoreanin B 抑制人单核细胞衍生巨噬细胞 (HMDM) 中的 M2 极化。Epimedokoreanin B 抑制 HMDMs 中的 STAT3 激活^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:	A549, Calu1 and H1299 cells
Concentration:	3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM
Incubation Time:	48 hours
Result:	Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.

Western Blot Analysis^[4]

Cell Line:	Human monocyte-derived macrophages (HMDMs)
Concentration:	5 μM
Incubation Time:	24 hours
Result:	Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.

体内研究
(In Vivo)

Epimedokoreanin B（20 mg/kg；口服；每周三次；持续 17 天）抑制 LM8 荷瘤鼠模型中的肿瘤生长^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C3H mice (8-10 weeks old) injected with LM8 cells^[4]
Dosage:	20 mg/kg
Administration:	Oral administration; thrice a week; for 17 days
Result:	Inhibited tumor growth.

体内研究

Epimedokoreanin B（20 mg/kg；口服；每周三次；持续 17 天）抑制 LM8 荷瘤鼠模型中的肿瘤生长^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C3H mice (8-10 weeks old) injected with LM8 cells^[4]
Dosage:	20 mg/kg
Administration:	Oral administration; thrice a week; for 17 days
Result:	Inhibited tumor growth.

体内研究

Epimedokoreanin B（20 mg/kg；口服；每周三次；持续 17 天）抑制 LM8 荷瘤鼠模型中的肿瘤生长^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C3H mice (8-10 weeks old) injected with LM8 cells^[4]
Dosage:	20 mg/kg
Administration:	Oral administration; thrice a week; for 17 days
Result:	Inhibited tumor growth.