N2-[芴甲氧羰基]-N6-[N-(1-氧代十六烷基)-L-GAMMA-谷氨酰]-L-赖氨酸1'-叔丁酯|Fmoc-Lys(Pal-Glu-OtBu)-OH|cas:1491158-62-3|西域试剂

N2-[芴甲氧羰基]-N6-[N-(1-氧代十六烷基)-L-GAMMA-谷氨酰]-L-赖氨酸1'-叔丁酯,Fmoc-Lys(Pal-Glu-OtBu)-OH,分析标准品,HPLC≥99%

产品编号：Bellancom-W045822| CAS NO：1491158-62-3| 分子式：C₄₆H₆₉N₃O₈| 分子量：792.06

Fmoc-Lys（Pal-Glu-OtBu）-OH是一种不可切割的ADC连接物，用于合成抗体药物结合物（ADC）。Fmoc-Lys（Pal-Glu-OtBu）-OH也是一种基于烷基链的PROTAC连接剂，可用于合成PROTAC。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-W045822		￥490.00	杭州北京（现货）

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N2-[芴甲氧羰基]-N6-[N-(1-氧代十六烷基)-L-GAMMA-谷氨酰]-L-赖氨酸1'-叔丁酯

产品介绍

Fmoc-Lys(Pal-Glu-OtBu)-OH 是可降解 (cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。Fmoc-Lys(Pal-Glu-OtBu)-OH 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

生物活性

Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs.

体外研究

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [Content Brief]

. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

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N2-[芴甲氧羰基]-N6-[N-(1-氧代十六烷基)-L-GAMMA-谷氨酰]-L-赖氨酸1'-叔丁酯,Fmoc-Lys(Pal-Glu-OtBu)-OH,分析标准品,HPLC≥99%

N2-[芴甲氧羰基]-N6-[N-(1-氧代十六烷基)-L-GAMMA-谷氨酰]-L-赖氨酸1'-叔丁酯

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