XL413 hydrochloride BMS-863233 hydrochloride|cas:2062200-97-7|西域试剂

XL413 hydrochloride BMS-863233 hydrochloride,99.82%

产品编号：Bellancom-15260A| CAS NO：2062200-97-7| 分子式：C₁₄H₁₃Cl₂N₃O₂| 分子量：326.18

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货号	价格	库存与货期
Bellancom-15260A	￥1330.00	杭州北京（现货）
Bellancom-15260A	￥1860.00	杭州北京（现货）
Bellancom-15260A	￥5580.00	杭州北京（现货）
Bellancom-15260A	￥8370.00	杭州北京（现货）

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XL413 hydrochloride BMS-863233 hydrochloride

产品介绍

XL413 (BMS-863233) hydrochloride 是一种有效的，选择性的，ATP 竞争性的 Cdc7 抑制剂，IC₅₀ 值为 3.4 nM，同时对 CK2 和 PIM1 的 IC₅₀ 值分别为 215 和 42 nM，对 pMCM 的 EC₅₀ 值为 118 nM。

生物活性

XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

体外研究

XL413 (BMS-863233) hydrochloride inhibits the cell proliferation (IC₅₀=2685 nM), decreases cell viability (IC₅₀=2142 nM) and elicits the caspase 3/7 activity (EC₅₀=2288 nM) in Colo-205 cells. XL413 hydrochloride also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC₅₀=715 nM).
XL413 hydrochloride shows cytotoxic effects on tumors, with IC₅₀ of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells. XL413 hydrochloride induces apoptosis in the Colo-205 cells, but not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC₅₀ of 22.7 nM. XL413 hydrochloride is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 10 mg/mL (30.66 mM; Need ultrasonic)

DMSO : 3.4 mg/mL (10.42 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0658 mL	15.3290 mL	30.6579 mL
5 mM	0.6132 mL	3.0658 mL	6.1316 mL
10 mM	0.3066 mL	1.5329 mL	3.0658 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献