PD-1/PD-L1-IN-14
产品编号：Bellancom-144258| CAS NO：2499965-12-5| 分子式：C24H24N4O2| 分子量：400.47
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PD-1/PD-L1-IN-14
| 产品介绍 | PD-1/PD-L1-IN-14 (compound 17) 是 PD-1/PD-L1 相互作用的抑制剂，其IC50 值为 27.8 nM。PD-1/PD-L1-IN-14 (compound 17) 抑制PD-1/PD-L1 相互作用，促进二聚化，内吞作用并降解 PD-L1。 |
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| 生物活性 | PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1. |
| 体外研究 |
PD-1/PD-L1-IN-14 (compound 17) promotes cell-surface PD-L1 internalized into the cytosol and induces the degradation of PD-L1 in tumor cells through a lysosome-dependent pathway. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 | |
| 体内研究 | |
| 性状 | |
| 溶解性数据 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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