KRIBB11|cas:342639-96-7|西域试剂

KRIBB11,99.12%

产品编号：Bellancom-100872| CAS NO：342639-96-7| 分子式：C₁₃H₁₂N₆O₂| 分子量：284.27

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货号	价格	库存与货期
Bellancom-100872	￥550.00	杭州北京（现货）
Bellancom-100872	￥800.00	杭州北京（现货）
Bellancom-100872	￥1800.00	杭州北京（现货）
Bellancom-100872	￥3000.00	杭州北京（现货）
Bellancom-100872	￥5400.00	杭州北京（现货）

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KRIBB11

产品介绍

KRIBB11 是 HSF1 的抑制剂，IC₅₀ 值为 1.2 μM。

生物活性

KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.

体外研究

KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 µM, and an IC₅₀ of 20-30 µM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 27 mg/mL (94.98 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5178 mL	17.5889 mL	35.1778 mL
5 mM	0.7036 mL	3.5178 mL	7.0356 mL
10 mM	0.3518 mL	1.7589 mL	3.5178 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式