Malabaricone B|cas:63335-24-0|西域试剂

Malabaricone B,99.0%

产品编号：Bellancom-N8517| CAS NO：63335-24-0| 分子式：C₂₁H₂₆O₄| 分子量：342.43

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N8517		￥3900.00	杭州北京（现货）

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Malabaricone B

产品介绍

Malabaricone B 是一种天然存在的植物酚类物质，是一种具有口服活性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂，IC₅₀ 为 63.7 µM。Malabaricone B 具有抗癌、抗菌、抗氧化和抗糖尿病活性。

生物活性

Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.

体外研究

Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC₅₀ = 8.1 μM), which is significantly better than that of curcumin (IC₅₀ = 26.7 μM).
The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3.
Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (292.03 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9203 mL	14.6015 mL	29.2030 mL
5 mM	0.5841 mL	2.9203 mL	5.8406 mL
10 mM	0.2920 mL	1.4602 mL	2.9203 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献