CDDO-3P-Im|cas:1883650-95-0|西域试剂

CDDO-3P-Im,98.19%

产品编号：Bellancom-135953| CAS NO：1883650-95-0| 分子式：C₃₉H₄₆N₄O₃| 分子量：618.81

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-135953	￥2500.00	杭州北京（现货）
Bellancom-135953	￥4000.00	杭州北京（现货）
Bellancom-135953	￥8000.00	杭州北京（现货）

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CDDO-3P-Im

产品介绍

CDDO-3P-Im 是 CDDO 咪唑胺类似物，具有化学预防作用。CDDO-3P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。CDDO-3P-Im 是一种具有口服活性的坏死 (necroptosis) 抑制剂，可用于缺血/再灌注 (I/R) 的研究。

生物活性

CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model. CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R).

体外研究

CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM.
CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC₅₀ of 4.3 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	U937 cells
Concentration:	30 nM, 100 nM
Incubation Time:	4 days
Result:	Induced differentiation of U937 cells at 30 nM.

体内研究
(In Vivo)

CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Seven week-old female A/J mice
Dosage:	50 mg/kg, 200 mg/kg
Administration:	Diet; for 16 weeks
Result:	Decreased the number, the size and the severity of tumors.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Seven week-old female A/J mice
Dosage:	50 mg/kg, 200 mg/kg
Administration:	Diet; for 16 weeks
Result:	Decreased the number, the size and the severity of tumors.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Seven week-old female A/J mice
Dosage:	50 mg/kg, 200 mg/kg
Administration:	Diet; for 16 weeks
Result:	Decreased the number, the size and the severity of tumors.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (404.00 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6160 mL	8.0800 mL	16.1600 mL
5 mM	0.3232 mL	1.6160 mL	3.2320 mL
10 mM	0.1616 mL	0.8080 mL	1.6160 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (3.36 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.36 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。