Hispolon|cas:173933-40-9|西域试剂

Hispolon,99.67%

产品编号：Bellancom-150521| CAS NO：173933-40-9| 分子式：C₁₂H₁₂O₄| 分子量：220.22

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货号	价格	库存与货期
Bellancom-150521	￥1900.00	杭州北京（现货）
Bellancom-150521	￥3000.00	杭州北京（现货）
Bellancom-150521	￥6000.00	杭州北京（现货）

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Hispolon

产品介绍

Hispolon 是一种多酚，可从桑黄 (Phellinus linteus) 中分离得到。Hispolon 具有抗癌、抗糖尿病、抗氧化、抗病毒、肝保护活性、抗糖尿病和抗炎活性。

生物活性

Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities.

体外研究

Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells.
Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells.
Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21.
Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	U87MG cells
Concentration:	25 and 50 μM
Incubation Time:	24, 48, 72 h
Result:	Inhibited cell viability in a dose and time dependent way.

Western Blot Analysis

Cell Line:	U87MG cells
Concentration:	25 and 50 μM
Incubation Time:	2, 4, 8 h
Result:	Decreased cyclin D4 level, and increased p21 level.

体内研究
(In Vivo)

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice.
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LPS-induced acute lung injury mice
Dosage:	2.5, 5 and 10 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Alleviated the pathological effects in the LPS-challenged mouse. Reduced the W/D ratio in the lung and MPO activity. Decreased pro-Inflammatory cytokine production.

Animal Model:	DBTRG xenograft mice^[4]
Dosage:	5 and 10 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Reduced tumor volume (RTV). Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.

体内研究

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice.
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LPS-induced acute lung injury mice
Dosage:	2.5, 5 and 10 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Alleviated the pathological effects in the LPS-challenged mouse. Reduced the W/D ratio in the lung and MPO activity. Decreased pro-Inflammatory cytokine production.

Animal Model:	DBTRG xenograft mice^[4]
Dosage:	5 and 10 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Reduced tumor volume (RTV). Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.

体内研究

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice.
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LPS-induced acute lung injury mice
Dosage:	2.5, 5 and 10 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Alleviated the pathological effects in the LPS-challenged mouse. Reduced the W/D ratio in the lung and MPO activity. Decreased pro-Inflammatory cytokine production.

Animal Model:	DBTRG xenograft mice^[4]
Dosage:	5 and 10 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Reduced tumor volume (RTV). Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (567.61 mM; ultrasonic and warming and heat to 70°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5409 mL	22.7046 mL	45.4091 mL
5 mM	0.9082 mL	4.5409 mL	9.0818 mL
10 mM	0.4541 mL	2.2705 mL	4.5409 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献