Ro 08-2750|cas:37854-59-4|西域试剂

Ro 08-2750,98.63%

产品编号：Bellancom-108466| CAS NO：37854-59-4| 分子式：C₁₃H₁₀N₄O₃| 分子量：270.24

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货号	价格	库存与货期
Bellancom-108466	￥1100.00	杭州北京（现货）
Bellancom-108466	￥3300.00	杭州北京（现货）
Bellancom-108466	￥4900.00	杭州北京（现货）
Bellancom-108466	￥8800.00	杭州北京（现货）
Bellancom-108466	￥13200.00	杭州北京（现货）

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Ro 08-2750

产品介绍

Ro 08-2750 是一种非肽、可逆的 NGF 抑制剂，能直接结合 NGF，IC₅₀ 值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75^NTR 的优于 TRKA。Ro 08-2750 是选择性的 MSI RNA 结合抑制剂，其作用的 IC₅₀ 值为 2.7 μM。

生物活性

Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC₅₀ of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75^NTR selectively over TRKA. Ro 08-2750 is a selective _{MSI RNA-binding} activity inhibitor, with an IC₅₀ of 2.7 μM.

体外研究

Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75^NTR anymore.
Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death.
Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells.
Ro 08-2750 inhibits survival of human AML lines and patient cells.
Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	MLL-AF9 + BM cells
Concentration:	5 μM, 10 μM
Incubation Time:	8 hours
Result:	Increased apoptosis.

体内研究
(In Vivo)

Ro 08-2750 (13.75 mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model
Dosage:	13.75 mg/kg
Administration:	Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug)
Result:	Inhibited c-MYC levels and reduced disease burden.

体内研究

Ro 08-2750 (13.75 mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model
Dosage:	13.75 mg/kg
Administration:	Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug)
Result:	Inhibited c-MYC levels and reduced disease burden.

体内研究

Ro 08-2750 (13.75 mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model
Dosage:	13.75 mg/kg
Administration:	Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug)
Result:	Inhibited c-MYC levels and reduced disease burden.

性状

Solid

溶解性数据

In Vitro:

DMSO : 4 mg/mL (14.80 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7004 mL	18.5021 mL	37.0041 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL
10 mM	0.3700 mL	1.8502 mL	3.7004 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式