Myricetin 杨梅素; Cannabiscetin|cas:529-44-2|西域试剂

Myricetin 杨梅素; Cannabiscetin,98.08%

产品编号：Bellancom-15097| CAS NO：529-44-2| 分子式：C₁₅H₁₀O₈| 分子量：318.24

Myricetin是常见的植物来源的类黄酮，具有广泛的活性，包括强抗氧化，抗癌，抗糖尿病和抗炎活性。杨梅素Myricetin 强力抑制酵母α-葡(萄)糖苷酶、葡(萄)糖苷酶I、体外葡(萄)糖苷酶I和牛奶中的黄嘌呤氧化酶。Myricetin具有对血小板活化因子(PAF) 的拮抗作用。Myricetin还具有抗血栓、抗心肌缺血、改善微循环等多方面的心血管药理作用。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-15097	￥500.00	杭州北京（现货）
Bellancom-15097	￥700.00	杭州北京（现货）
Bellancom-15097	￥1000.00	杭州北京（现货）
Bellancom-15097	￥1900.00	杭州北京（现货）

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Myricetin 杨梅素; Cannabiscetin

产品介绍

Myricetin是常见的植物来源的类黄酮，具有广泛的活性，包括强抗氧化，抗癌，抗糖尿病和抗炎活性。

生物活性

Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.

体外研究

Myricetin exhibits the scavenging activity towards a number of radicals and ions. It displays poor activity (IC₅₀ value=1.4 mg/mL) in a superoxide dismutase (SOD)-like activity assay. It prevents cancer cell death via apoptosis via regulation of PI3K/Akt and MAPK signalling pathways. Myricetin exhibits antiphotoaging effects by quenching causative free radicals in the skin. Myricetin is able to suppress UVB-induced COX-2 expression in mouse skin epidermal JB6 P+ cells. It inhibits UVB-induced initiation of activator protein-1 and NF-κβ, as well as Fyn kinase activity. Myricetin inhibits viability of SKOV3 ovarian cancer cells in a dose-dependent manner. It induces DNA DSBs and ER stress, which leads to apoptosis in SKOV3 cells. Myricetin inhibits human Hsp70 by more than 80% with IC₅₀ values of 83, 11 and 12 μM, respectively^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Treatment of orthotopic pancreatic tumors with myricetin results in tumor regression and decreases metastatic spread. Exposure to 150 μM myricetin causes 14%, 26%, 5% and 49% inhibition of rabbit platelet aggregation, induced by ADP, arachidonic acid, collagen and PAF, respectively^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 31 mg/mL (97.41 mM)

Ethanol : 28.57 mg/mL (89.78 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1423 mL	15.7114 mL	31.4228 mL
5 mM	0.6285 mL	3.1423 mL	6.2846 mL
10 mM	0.3142 mL	1.5711 mL	3.1423 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (6.54 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (6.54 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Semwal DK, et al. Myricetin: A Dietary Molecule with Diverse Biological Activities. Nutrients. 2016 Feb 16;8(2):90. [Content Brief]

. Phillips PA, et al. Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of thephosphatidylinositol 3-kinase (PI3K) signaling pathway. Cancer Lett. 2011 Sep 28;308(2):181-8. [Content Brief]

. Xu Y, et al. Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells. Mol Med Rep. 2016 Mar;13(3):2094-100. [Content Brief]

[4]. Jinwal UK, et al. Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability. J Neurosci. 2009 Sep 30;29(39):12079-88. [Content Brief]

[5]. Tzeng SH, et al. Inhibition of platelet aggregation by some flavonoids. Thromb Res. 1991 Oct 1;64(1):91-100. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	S24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	LK8646000
海关编码	2914501900

1. 物质的识别

产品名：	Myricetin
CAS号：	529-44-2
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Myricetin
别名：	Cannabiscetin
分子式：	C15H10O8
分子量：	318.24

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	4°C, protect from light, dry, sealed

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 4
17912-87-7 15648-86-9 557792-97-9 10034-85-2
下游产品 7
108-73-6 149-91-7 15648-86-9 15868-40-3
14290-57-4 14813-29-7 53472-37-0

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4. 韩林, 刘益, 罗梅,等. 杨梅素对α-葡萄糖苷酶的抑制活性机理研究[J]. 食品工业科技, 2017, 038(022):51-55,60.

3. 王轶博, 符晓芳, 袁丽,等. 杨梅素与G-β-CD的包合作用及抗氧化性分析[J]. 食品科学, 2020, 41(4).

2. 罗婷婷, 杨明, 熊小平,等. 多种植物油中黄酮和角鲨烯分布UPLC研究[J]. 中国测试, 2018(8):62-69.

1. 张迪文,马开,田萍,郭晓燕.基于多波长HPLC指纹图谱结合化学计量分析的金花葵质量评价研究[J].中草药,2019,50(14):3426-3432.

Myricetin 杨梅素; Cannabiscetin,98.08%

Myricetin 杨梅素; Cannabiscetin

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