Amantadine hydrochloride 盐酸金刚烷胺; 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride|cas:665-66-7|西域试剂

Amantadine hydrochloride 盐酸金刚烷胺; 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride,98.0%

产品编号：Bellancom-B0402A| CAS NO：665-66-7| 分子式：C₁₀H₁₈ClN| 分子量：187.71

Amantadine盐酸盐是抗流感病毒和抗帕金森病化合物。

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货号	价格	库存与货期
Bellancom-B0402A	￥400.00	杭州北京（现货）
Bellancom-B0402A	￥600.00	杭州北京（现货）
Bellancom-B0402A	￥800.00	杭州北京（现货）
Bellancom-B0402A	￥1300.00	杭州北京（现货）

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Amantadine hydrochloride 盐酸金刚烷胺; 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride

产品介绍

Amantadine (1-Adamantanamine) hydrochloride 是一种口服有效的抗甲型流感 (influenza A) 病毒的抗病毒剂。Amantadine hydrochloride 对 NMDA、M2 等多种离子通道均有抑制作用。Amantadine hydrochloride 还具有抗正痘病毒 (orthopoxvirus) 和抗癌活性。Amantadine hydrochloride 可用于帕金森病，术后认知功能障碍 (POCD) 和 COVID-19 的研究。

生物活性

Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research^[4]^[5]^[6].

体外研究

Amantadine hydrochloride (0-500 µM, 26 h) inhibits SARS-CoV-2 replication, with IC₅₀ concentrations between 83 and 119 µM^[4].
Amantadine hydrochloride (0-100 µg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC‑7721 cells^[6].
Amantadine hydrochloride (0-75 µg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis^[6].
Amantadine hydrochloride (0-75 µg/mL, 48 h) reduces the levels of the cell cycle‑related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels^[6].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	Vero E6 cells
Concentration:	500 µM, 100 µM, 20 µM, 4 µM, and 8 nM
Incubation Time:	26 h
Result:	Caused a concentration-dependent reduction (IC₅₀=83 µM) of viral nucleic acids in the supernatant 26 h after infection at 10-500 µM. Caused a concentration-dependent reduction (IC₅₀=119 µM) of viral nucleic acids in the cytosol 26 h after infection.

Cell Proliferation Assay^[6]

Cell Line:	Human HCC cell lines (HepG2 and SMMC-7721) and normal hepatocellular cells (L02 cells)
Concentration:	0, 1, 2, 5, 10, 25, 50 and 100 µg/mL
Incubation Time:	24, 48 and 72 h
Result:	Inhibited cellular proliferation in a time- and dose-dependent manner in HepG2 and SMMC-7721 cells.

Cell Cycle Analysis^[6]

Cell Line:	HepG2 and SMMC-7721 cells
Concentration:	0, 10, 25, 50 and 75 µg/mL
Incubation Time:	48 h
Result:	Significantly increased the population of HepG2 and SMMC-7721 cells in the G0/G1 phase in a dose-dependent manner, and significantly decreased the number of HepG2 cells in the S phase.

Apoptosis Analysis^[6]

Cell Line:	HepG2 and SMMC-7721 cells
Concentration:	0, 10, 25, 50 and 75 µg/mL
Incubation Time:	48 h
Result:	Markedly increased the percentage of apoptotic HepG2 and SMMC-7721 cells (early- and late-stage apoptosis) in a dose-dependent manner.

Western Blot Analysis^[6]

Cell Line:	HepG2 and SMMC-7721 cells
Concentration:	0, 10, 25, 50 and 75 µg/mL
Incubation Time:	48 h
Result:	Showed downregulation of cyclin D1, cyclin E and CDK2, and showed a decrease in Bcl-2 levels and an increase of Bax levels in HepG2 and SMMC-7721 cells.

RT-PCR^[6]

Cell Line:	HepG2 and SMMC-7721 cells
Concentration:	0, 10, 25, 50 and 75 µg/mL
Incubation Time:	48 h
Result:	Revealed an increase in Bax and decrease in Bcl-2 genes.

体内研究
(In Vivo)

Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)^[5]
Dosage:	25 mg/kg
Administration:	IP, once daily for 3 days (the first dose at 15 min before surgery)
Result:	Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.

体内研究

Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)^[5]
Dosage:	25 mg/kg
Administration:	IP, once daily for 3 days (the first dose at 15 min before surgery)
Result:	Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.

体内研究

Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)^[5]
Dosage:	25 mg/kg
Administration:	IP, once daily for 3 days (the first dose at 15 min before surgery)
Result:	Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (532.74 mM; Need ultrasonic)

H₂O : ≥ 50 mg/mL (266.37 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.3274 mL	26.6368 mL	53.2737 mL
5 mM	1.0655 mL	5.3274 mL	10.6547 mL
10 mM	0.5327 mL	2.6637 mL	5.3274 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 6.88 mg/mL (36.65 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [Content Brief]

. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. [Content Brief]

. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [Content Brief]

[4]. Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. [Content Brief]

[5]. Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. [Content Brief]

[6]. Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn:Harmful
风险声明 (欧洲)	R22
安全声明 (欧洲)	S22-S36/37
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	AU4375000
海关编码	2921300090

1. 物质的识别

产品名：	Amantadine hydrochloride
CAS号：	665-66-7
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Amantadine hydrochloride
别名：	1-adamantanamine HCl
分子式：	C10H17N.HCl
分子量：	187.7

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

24886-73-5

~97%

665-66-7

文献：Hays, David S.; Fu, Gregory C. Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2796 - 2797

57680-77-0

~82%

665-66-7

文献：Tsutsui, Hironori; Ichikawa, Tomoko; Narasaka, Koichi Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 8 p. 1869 - 1878

880-52-4

665-66-7

文献：Organic Letters, , vol. 11, # 2 p. 433 - 436

768-94-5

665-66-7

文献：WO2007/96124 A1, ; Page/Page column 15-16 ;

17341-91-2

~10%

665-66-7

文献：Huard, Kim; Lebel, Helene Chemistry - A European Journal, 2008 , vol. 14, # 20 p. 6222 - 6230

24375-06-2

24375-05-1

665-66-7

文献：Journal of Organic Chemistry, , vol. 45, # 26 p. 5239 - 5243

上游产品 5
24886-73-5 57680-77-0 880-52-4 768-94-5
24375-06-2
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3717-60-0 4411-25-0 5689-59-8 22110-53-8
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