SMER28|cas:307538-42-7|西域试剂

SMER28,99.99%

产品编号：Bellancom-100200| CAS NO：307538-42-7| 分子式：C₁₁H₁₀BrN₃| 分子量：264.12

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-100200	￥500.00	杭州北京（现货）
Bellancom-100200	￥700.00	杭州北京（现货）
Bellancom-100200	￥1400.00	杭州北京（现货）
Bellancom-100200	￥2700.00	杭州北京（现货）
Bellancom-100200	￥5200.00	杭州北京（现货）

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SMER28

产品介绍

SMER28 是一个调节自噬的、独立于 mTOR 信号通路机制的小分子阳性调节剂，能够阻止β淀粉样蛋白肽的累积。

生物活性

SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

体外研究

SMER28 (5-200 μM; 24 hours) shows a dose dependent decline of cell viability^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	MMS1 cells
Concentration:	5, 25, 50, 75, 100, 150, 200 μM
Incubation Time:	24 hours
Result:	Showed a dose dependent decline of cell viability.

体内研究
(In Vivo)

SMER28 (15-65 mg/kg; i.h.; daily, two days before irradiation and during the three days of irradiation) significantly protects against post-irradiation weight loss and enhances survival of mice at 65 mg/kg^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	14 to 16 weeks male mice (Balb/c)^[5]
Dosage:	15, 65 mg/kg
Administration:	Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days)
Result:	Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	14 to 16 weeks male mice (Balb/c)^[5]
Dosage:	15, 65 mg/kg
Administration:	Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days)
Result:	Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	14 to 16 weeks male mice (Balb/c)^[5]
Dosage:	15, 65 mg/kg
Administration:	Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days)
Result:	Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 32 mg/mL (121.16 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7862 mL	18.9308 mL	37.8616 mL
5 mM	0.7572 mL	3.7862 mL	7.5723 mL
10 mM	0.3786 mL	1.8931 mL	3.7862 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.47 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.47 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.47 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.47 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.47 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.47 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。