Folitixorin 5,10-Methylenetetrafolate; ANX-510 free acid|cas:3432-99-3|西域试剂

Folitixorin 5,10-Methylenetetrafolate; ANX-510 free acid,94.87%

产品编号：Bellancom-14769| CAS NO：3432-99-3| 分子式：C₂₀H₂₃N₇O₆| 分子量：457.44

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-14769		￥2800.00	杭州北京（现货）
Bellancom-14769		￥8500.00	杭州北京（现货）

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Folitixorin 5,10-Methylenetetrafolate; ANX-510 free acid

产品介绍

Folitixorin (5,10-methylenetetrahydrofolate) 是一种辅助因子和亚叶酸的类似物。Folitixorin 是一种在辅助肿瘤研究中调节 5-FU 细胞毒性的有潜力的试剂。

生物活性

Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research.

体外研究

5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahy-drofolate, which is the major circulating form of folate.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

A colon adenocarcinoma cell suspension is inoculated intrahepatically in a rodent experimental model. Intravenous 5-FU (30 mg/kg) in combination with Folitixorin (15 mg/kg or 30 mg/kg) is administered after 1, 2, 3, 4 and 7 days. 5-FU in combination with Folitixorin (regardless of folate-dose) eliminats tumor take.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 5 mg/mL (10.93 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1861 mL	10.9304 mL	21.8608 mL
5 mM	0.4372 mL	2.1861 mL	4.3722 mL
10 mM	0.2186 mL	1.0930 mL	2.1861 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-80°C, protect from light, stored under nitrogen

参考文献