Imisopasem manganese M40403; GC4403|cas:218791-21-0|西域试剂

Imisopasem manganese M40403; GC4403,96.0%

产品编号：Bellancom-13336| CAS NO：218791-21-0| 分子式：C₂₁H₃₁Cl₂MnN₅| 分子量：479.35

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货号	价格	库存与货期
Bellancom-13336	￥990.00	杭州北京（现货）
Bellancom-13336	￥1700.00	杭州北京（现货）
Bellancom-13336	￥2700.00	杭州北京（现货）
Bellancom-13336	￥5400.00	杭州北京（现货）
Bellancom-13336	￥8500.00	杭州北京（现货）

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Imisopasem manganese M40403; GC4403

产品介绍

Imisopasem manganese (M40403) 是稳定的 MnSOD 的非肽基模拟物。

生物活性

Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD.

体外研究

Imisopasem manganese is a small molecule, synthetic manganese containing superoxide dismutase mimetic (SODm) that removes superoxide anions without interfering with other reactive species known to be involved in inflammatory responses (e.g. nitric oxide, NO and peroxynitrite, ONOO-).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Imisopasem manganese is a small-molecule superoxide dismutase mimetic that has shown efficacy in animal model disease states in which superoxide anions are thought to play a key role. Imisopasem manganese inhibits the inflammatory response following the intrapleural injection of carrageenan in rats. All parameters of inflammation are attenuated by Imisopasem manganese except for NOx, PGE2 and IL-10 which remains unaltered. Decreased apoptosis of the large and particularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in the Imisopasem manganese pre-treated mice. Imisopasem manganese is effective in reducing TBI-induced tissue destruction and has potential as a new radioprotective agent.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 25 mg/mL (52.15 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0862 mL	10.4308 mL	20.8616 mL
5 mM	0.4172 mL	2.0862 mL	4.1723 mL
10 mM	0.2086 mL	1.0431 mL	2.0862 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶