L748337|cas:244192-94-7|西域试剂

L748337,99.67%

产品编号：Bellancom-103211| CAS NO：244192-94-7| 分子式：C₂₆H₃₁N₃O₅S| 分子量：497.61

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-103211	￥1800.00	杭州北京（现货）
Bellancom-103211	￥2900.00	杭州北京（现货）
Bellancom-103211	￥5700.00	杭州北京（现货）
Bellancom-103211	￥9100.00	杭州北京（现货）
Bellancom-103211	￥14600.00	杭州北京（现货）

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L748337

产品介绍

L748337 是一种有效的 β3-肾上腺素能受体 (β3-adrenergic receptor) 拮抗剂，对 β1 和 β2 受体具有选择性。L748337 对 β3-、β2- 和 β1-肾上腺素受体的 K_i 值分别为 4.0 nM、204 nM 和 390 nM。L748337 主要与 G_i 结合激活 MAPK 信号并增加 Erk1/2 的磷酸化，其 pEC₅₀ 值为 11.6。L748337 可用于癌症、非酒精性脂肪性肝病 (NAFLD) 及心血管相关等疾病的研究。

生物活性

L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The K_i values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to G_i to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC₅₀ value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.

体外研究

L748337 (1 μM) inhibits iNOS expression in B16F10 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

L-748337 (intraperitoneal injection; 5 mg/kg; beginning 10 days until D18) decreases the growth of melanoma induced by B16F10 cell inoculation and decreases tumor vasculature in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Fifty male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cell
Dosage:	5 mg/kg
Administration:	Beginning 10 days until D18
Result:	Exhibited anti-cancer effects.

体内研究

L-748337 (intraperitoneal injection; 5 mg/kg; beginning 10 days until D18) decreases the growth of melanoma induced by B16F10 cell inoculation and decreases tumor vasculature in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Fifty male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cell
Dosage:	5 mg/kg
Administration:	Beginning 10 days until D18
Result:	Exhibited anti-cancer effects.

性状

Solid

溶解性数据

In Vitro:

Ethanol : 30 mg/mL (60.29 mM; Need ultrasonic and warming)

DMSO : 25 mg/mL (50.24 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0096 mL	10.0480 mL	20.0961 mL
5 mM	0.4019 mL	2.0096 mL	4.0192 mL
10 mM	0.2010 mL	1.0048 mL	2.0096 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献