MC-GGFG-Exatecan MC-GGFG-DX8951|cas:1600418-29-8|西域试剂

MC-GGFG-Exatecan MC-GGFG-DX8951,99.71%

产品编号：Bellancom-114233| CAS NO：1600418-29-8| 分子式：C₄₉H₅₁FN₈O₁₁| 分子量：946.97

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-114233		￥9000.00	杭州北京（现货）
Bellancom-114233		￥15000.00	杭州北京（现货）

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MC-GGFG-Exatecan MC-GGFG-DX8951

产品介绍

MC-GGFG-Exatecan (MC-GGFG-DX8951) 是一种抗体偶联活性分子 (drug-linker conjugate for ADC)，由DNA拓扑异构酶 I 抑制剂 DX8951 和蛋白酶可降解 (cleavable) 的 MC-GGFG 连接而成。MC-GGFG-Exatecan 表现出抗肿瘤活性，可用于制备 DX8951 抗体结合物 (ADC)。

生物活性

MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC).

体外研究

In MC-GGFG-Exatecan, GGFG is selectively cleaved by lysosomal enzymes (presumably cathepsins).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In MC-GGFG-Exatecan, GGFG is known to release drugs into tumor tissue without releasing them into peripheral circulation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In MC-GGFG-Exatecan, GGFG is known to release drugs into tumor tissue without releasing them into peripheral circulation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (52.80 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0560 mL	5.2800 mL	10.5600 mL
5 mM	0.2112 mL	1.0560 mL	2.1120 mL
10 mM	0.1056 mL	0.5280 mL	1.0560 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式