Demethylcantharidate disodium|cas:129-67-9|西域试剂

Demethylcantharidate disodium,98.0%

产品编号：Bellancom-N1443| CAS NO：129-67-9| 分子式：C₈H₈Na₂O₅| 分子量：230.13

去甲基斑蝥酸二钠是一种内源性代谢产物,通过内质网应激诱导肝癌细胞凋亡。去甲基斑蝥酸二钠对多种类型的癌症具有极好的抗癌活性。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N1443		￥500.00	杭州北京（现货）

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Demethylcantharidate disodium

产品介绍

Demethylcantharidate disodium 是一种内源性代谢产物，通过内质网应激诱导肝癌细胞凋亡。Demethylcantharidate disodium 对多种类型的癌症具有良好的抗癌活性。

生物活性

Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer.

体外研究

Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation.
Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HCC cell lines (SMMC-7721 and Bel-7402)
Concentration:	0-100 μM
Incubation Time:	0, 12, 24, 48 or 72 hours
Result:	Showed anti-proliferative activity in the two HCC cell lines.

Cell Viability Assay

Cell Line:	HCC cells
Concentration:	0, 9, 18 or 36 µM
Incubation Time:	24 hours
Result:	Induced apoptosis in HCC cells via the intrinsic pathway.

体内研究
(In Vivo)

Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 33.33 mg/mL (144.83 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.3454 mL	21.7269 mL	43.4537 mL
5 mM	0.8691 mL	4.3454 mL	8.6907 mL
10 mM	0.4345 mL	2.1727 mL	4.3454 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (217.27 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献

. Ye M, et al. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. Am J Transl Res. 2019;11(5):3150-3158. Published 2019 May 15. [Content Brief]

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产品编号(Item Number)

批号(Lot Number)

风险声明 (欧洲)	21-25-36/37/38
危险品运输编码	UN 2588
包装等级	II
危险类别	6.1(a)

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Demethylcantharidate disodium,98.0%

Demethylcantharidate disodium

化学品安全说明书(MSDS)

质检证书(COA)

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