Prodigiosin hydrochloride Prodigiosine hydrochloride|cas:56144-17-3|西域试剂

Prodigiosin hydrochloride Prodigiosine hydrochloride,98.00%

产品编号：Bellancom-100711A| CAS NO：56144-17-3| 分子式：C₂₀H₂₆ClN₃O| 分子量：359.89

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货号	价格	库存与货期
Bellancom-100711A	￥1500.00	杭州北京（现货）
Bellancom-100711A	￥3750.00	杭州北京（现货）
Bellancom-100711A	￥6200.00	杭州北京（现货）

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Prodigiosin hydrochloride Prodigiosine hydrochloride

产品介绍

Prodigiosin (Prodigiosine) hydrochloride，一种天然的红色素，是一种具有生物活性的次生代谢产物。Prodigiosin hydrochloride 是一种有效的促凋亡剂，可抑制 Wnt/β-catenin 通路。Prodigiosin hydrochloride 具有抗菌，抗真菌，抗原生动物，抗疟疾，免疫抑制和抗癌特性。

生物活性

Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.

体外研究

Prodigiosin (25-500 nM; 24 hours) treatment reduces the viability of breast cancer cells, with IC₅₀ values at 48 h of 62.52 nM in MDA-MB-231 cells and 261.2 nM in MDA-MB-468 cells.
Prodigiosin (25-500 nM; 24 hours) treatment significantly reduces the levels of phosphorylated LRP6 and DVL2, active β-catenin, and total β-catenin. Prodigiosin noticeably inhibits the phosphorylation of GSK3β at Ser9 in HEK293T cells, which is indicative of an increase in GSK3β activity.
Prodigiosin can inhibit proliferation and induce apoptosis in breast cancer cells.
Prodigiosin (25-500 nM; 24 hours) treatment dose-dependently blocks Wnt signaling activated by Wnt1, Wnt3, Wnt1/LRP6, Wnt3/LRP6, and Dishevelled 2 (DVL2) in transfected HEK293T cells. Prodigiosin treatment inhibits Wnt3A-CM-induced transcription in a dose-dependent manner. Prodigiosin inhibits transcription of the SuperTopFlash reporter activated by either Wnt transfection or Wnt3A treatment.
When applied to cultures of chytrid fungi Batrachochytrium dendrobatidis and B. salamandrivorans, Prodigiosin causes significant growth inhibition, with MIC values of 10 μM and 50 μM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	MDA-MB-231 and MDA-MB-468 cells
Concentration:	10 nM, 25 nM, 50 nM, 100 nM, 250 nM, 500 nM, 1000 nM, 2500 nM, 5000 nM
Incubation Time:	24 hours, 48 hours
Result:	Reduced the viability of breast cancer cells, with IC50 values at 48 h of 62.52 nM in MDA-MB-231 cells and 261.2 nM in MDA-MB-468 cells.

Western Blot Analysis

Cell Line:	HEK293T cells
Concentration:	50 nM, 100 nM, 250 nM, 500 nM
Incubation Time:	24 hours
Result:	Significantly reduced the levels of phosphorylated LRP6 and DVL2, active β-catenin, and total β-catenin.

体内研究
(In Vivo)

Prodigiosin (5 mg/kg; intraperitoneal injection; twice weekly; for 3 weeks) treatment significantly inhibits tumor growth. Prodigiosin treatment decreases tumor cell density and expression of the proliferation marker Ki-67.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice injected with MDA-MB-231 cells
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; twice weekly; for 3 weeks
Result:	Significantly inhibited tumor growth in mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice injected with MDA-MB-231 cells
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; twice weekly; for 3 weeks
Result:	Significantly inhibited tumor growth in mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice injected with MDA-MB-231 cells
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; twice weekly; for 3 weeks
Result:	Significantly inhibited tumor growth in mice.