Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Fmoc-Thr(Ac₃AcNH-α-Gal-OH)|cas:116783-35-8|西域试剂

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Fmoc-Thr(Ac₃AcNH-α-Gal-OH),98.36%

产品编号：Bellancom-P0232| CAS NO：116783-35-8| 分子式：C₃₃H₃₈N₂O₁₃| 分子量：670.66

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是用于研究制备癌症疫苗的结构单元。

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货号	价格	库存与货期
Bellancom-P0232	￥2950.00	杭州北京（现货）
Bellancom-P0232	￥5200.00	杭州北京（现货）
Bellancom-P0232	￥8100.00	杭州北京（现货）

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Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Fmoc-Thr(Ac₃AcNH-α-Gal-OH)

产品介绍

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是用于研究制备癌症疫苗的结构单元。

生物活性

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

体外研究

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (149.11 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4911 mL	7.4553 mL	14.9107 mL
5 mM	0.2982 mL	1.4911 mL	2.9821 mL
10 mM	0.1491 mL	0.7455 mL	1.4911 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture