Norathyriol Mangiferitin|cas:3542-72-1|西域试剂

Norathyriol Mangiferitin,99.83%

产品编号：Bellancom-N1029| CAS NO：3542-72-1| 分子式：C₁₃H₈O₆| 分子量：260.20

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货号	价格	库存与货期
Bellancom-N1029	￥3600.00	杭州北京（现货）
Bellancom-N1029	￥6400.00	杭州北京（现货）
Bellancom-N1029	￥13200.00	杭州北京（现货）

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Norathyriol Mangiferitin

产品介绍

Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase )，IC₅₀ 为 3.12 μM。Norathyriol 还抑制 PPARα、PPARβ 和 PPARγ，IC₅₀ 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。

生物活性

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC₅₀ of 3.12 μM. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC₅₀s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

体外研究

Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest.
Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells Cell Growth Assay WB

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Mouse skin epidermal JB6 P+ cells
Concentration:	0, 1, 10, or 25 µM
Incubation Time:	24 or 72 hours
Result:	Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death.

Western Blot Analysis

Cell Line:	JB6 P+ cells
Concentration:	0, 1, 10, or 25 µM
Incubation Time:	2 hours
Result:	Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

体内研究
(In Vivo)

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety.
Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult Kunming mice weighing 18-22 g^[4]
Dosage:	0.92, 1.85 and 3.7 mg/kg
Administration:	Administered intragastrically; twice daily for five times
Result:	The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult Kunming mice weighing 18-22 g^[4]
Dosage:	0.92, 1.85 and 3.7 mg/kg
Administration:	Administered intragastrically; twice daily for five times
Result:	The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult Kunming mice weighing 18-22 g^[4]
Dosage:	0.92, 1.85 and 3.7 mg/kg
Administration:	Administered intragastrically; twice daily for five times
Result:	The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (384.32 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8432 mL	19.2160 mL	38.4320 mL
5 mM	0.7686 mL	3.8432 mL	7.6864 mL
10 mM	0.3843 mL	1.9216 mL	3.8432 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.61 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.61 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.61 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。