BAY-0069|cas:420826-65-9|西域试剂

BAY-0069,98.07%

产品编号：Bellancom-148351| CAS NO：420826-65-9| 分子式：C₂₂H₁₆BrN₃O₄| 分子量：466.28

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货号	价格	库存与货期
Bellancom-148351	￥1000.00	杭州北京（现货）
Bellancom-148351	￥1600.00	杭州北京（现货）
Bellancom-148351	￥3500.00	杭州北京（现货）
Bellancom-148351	￥5500.00	杭州北京（现货）
Bellancom-148351	￥8500.00	杭州北京（现货）

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BAY-0069

产品介绍

BAY-0069 是一种有效且具有选择性的 PPARγ 反向激活剂，对人 PPARγ 和鼠 PPARγ 的 IC₅₀ 分别为 6.3 nM 和 24 nM。BAY-0069 可用于癌症的研究。

生物活性

BAY-0069 is a potent and selective PPARγ inverse agonist with an IC₅₀ value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer.

体外研究

BAY-0069 inhibits CYP2C8 with an IC₅₀ of 4.3 μM.
BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	PPARγ-amplified cell line UM-UC-9
Concentration:	0.0001, 0.001, 0.01, 0.01 and 1 μM
Incubation Time:	7 days
Result:	Inhibited PPARγ-amplified cell line UM-UC-9 with an IC₅₀ of 2.54 nM.

体内研究
(In Vivo)

BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CL_b,hmic of 0.47 L/h/kg in human liver microsomes and CL_b,rhep of 3.9 L/h/kg in rat liver hepatocytes.
Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice.

Route	P.O. (100 mg/kg)	I.P.	S.C.
AUC_0-tlast (mg/L·h)	0.074	0.26	0.045
C_max (nM)	35	59	4.4

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Route	P.O. (100 mg/kg)	I.P.	S.C.
AUC_0-tlast (mg/L·h)	0.074	0.26	0.045
C_max (nM)	35	59	4.4

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Route	P.O. (100 mg/kg)	I.P.	S.C.
AUC_0-tlast (mg/L·h)	0.074	0.26	0.045
C_max (nM)	35	59	4.4

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (214.46 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1446 mL	10.7232 mL	21.4463 mL
5 mM	0.4289 mL	2.1446 mL	4.2893 mL
10 mM	0.2145 mL	1.0723 mL	2.1446 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式